Apoptosis in non-proliferating cells: implications for viral infection and tumourigenesis

被引:4
作者
Borodyansky, L [1 ]
Li, YZ [1 ]
Pardee, AB [1 ]
Li, CJ [1 ]
机构
[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Div Cell Growth & Regulat, Boston, MA 02115 USA
关键词
AIDS; apoptosis; cell cycle; cell quiescence; HIV-1; infection; tumourigenesis;
D O I
10.1023/A:1009693517181
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
To date much attention has been focused on regulation of apoptosis in proliferating cells. However, recent evidence shows that regulation of apoptosis in quiescent tissue plays an important role in homeostasis of the organism. This review examines the implications of apoptosis of quiescent cells for both tumourigenesis and viral infection such as HIV. In this article we propose a dual role for cellular activation in the homeostasis regulation. In this model cellular mitogens not only activate quiescent cells into the active cell cycle, but under certain conditions, loss of quiescence may result in apoptosis. The loss of quiescence-associated apoptosis may play a significant role in tumourigenesis and viral infections.
引用
收藏
页码:381 / 385
页数:5
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