Modulatory role of grape seed extract on age-related oxidative DNA damage in central nervous system of rats

被引：71

作者：

Balu, M ^{[1
]}

Sangeetha, P ^{[1
]}

Murali, G ^{[1
]}

Panneerselvam, C ^{[1
]}

机构：

[1] Univ Madras, Dr ALM Post Grad Inst Basic Med Sci, Dept Med Biochem, Madras 600113, Tamil Nadu, India

来源：

BRAIN RESEARCH BULLETIN | 2006年 / 68卷 / 06期

关键词：

aging; central nervous system; 8-OHdG; DNA protein cross-links; grape seed extract;

D O I：

10.1016/j.brainresbull.2005.10.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Aging is the accumulation of diverse deleterious changes in the cells and tissues leading to increased risk of diseases. Oxidative stress is considered as a major risk factor and contributes to age related increase in DNA oxidation and DNA protein cross-links in central nervous system during aging. In the present study, we have evaluated the salubrious role of grape seed extract on accumulation of oxidative DNA damage products such as 8-OHdG and DNA protein cross-links in aged rats. Male albino rats of Wistar strain were divided into four groups: Group I, young control rats; Group II, young rats treated with grape seed extract (100 mg/kg b.wt.) for 30 days; Group III, aged control rats: Group IV, aged rats supplemented with grape seed extract (100 mg/kg b.wt.) for 30 days. Our results, thus, revealed that grape seed extract has inhibiting effect on the accumulation of age-related oxidative DNA damages in spinal cord and in various brain regions such as cerebral cortex. striatum and hippocampus. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：469 / 473

页数：5

共 37 条

[1]

Oxidative DNA damage in the parkinsonian brain: An apparent selective increase in 8-hydroxyguanine levels in substantia nigra [J].