Carboxamide-pyridine N-oxide heterosynthon for crystal engineering and pharmaceutical cocrystals

被引：140

作者：

Reddy, LS ^{[1
]}

Babu, NJ ^{[1
]}

Nangia, A ^{[1
]}

机构：

[1] Univ Hyderabad, Sch Chem, Hyderabad 500046, Andhra Pradesh, India

来源：

CHEMICAL COMMUNICATIONS | 2006年 / 13期

关键词：

D O I：

10.1039/b515510j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The novel carboxamide-pyridine N-oxide synthon, sustained via N-H center dot center dot center dot O- hydrogen bonding and C-H center dot center dot center dot O interaction, is shown to assemble isonicotinamide N-oxide in a triple helix architecture and the same heterosynthon is exploited to synthesize cocrystals of barbiturate drugs with 4,4'- bipyridine N, N'\- dioxide.

引用

页码：1369 / 1371

页数：3

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