Prostanoids and inflammatory pain

被引：77

作者：

Chen, Lihong ^{[1
]}

Yang, Guangrui ^{[1
]}

Grosser, Tilo ^{[1
]}

机构：

[1] Univ Penn, Inst Translat Med & Therapeut, Philadelphia, PA 19104 USA

来源：

PROSTAGLANDINS & OTHER LIPID MEDIATORS | 2013年 / 104卷

关键词：

Inflammatory pain; COX-2; PGE(2); PGI(2); mPGES-1; Peripheral sensitization; Central sensitization; SPINAL PROSTAGLANDIN E-2; GENE-RELATED PEPTIDE; RAT SENSORY NEURONS; DORSAL-HORN NEURONS; COLLAGEN-INDUCED ARTHRITIS; EP4 RECEPTOR ANTAGONIST; CYCLOOXYGENASE ISOFORMS; MESSENGER-RNA; MICE LACKING; PGE(2)-INDUCED SENSITIZATION;

D O I：

10.1016/j.prostaglandins.2012.08.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Prostanoids play pivotal roles in inflammation and pain. Cyclooxygenase (COX) inhibitors, the nonsteroidal anti-inflammatory drugs (NSAIDs), depress prostanoid formation and are widely used to treat inflammatory pain. However, their therapeutic benefit is offset by serious side-effects, primarily gastrointestinal and cardiovascular complications. Pathway elements downstream of the COX enzymes, particularly the terminal synthases and receptors of prostaglandin E-2, have been proposed as alternative targets for the development of novel NSAID like drugs. Here, we summarize the current knowledge on the roles of individual prostanoids in modulating inflammatory pain. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：58 / 66

页数：9

共 131 条

[1]

The cell and molecular basis of mechanical, cold, and inflammatory pain [J].

Abrahamsen, Bjarke ;

Zhao, Jing ;

Asante, Curtis O. ;

Cendan, Cruz Miguel ;

Marsh, Steve ;

Martinez-Barbera, Juan Pedro ;

Nassar, Mohammed A. ;

Dickenson, Anthony H. ;

Wood, John N. .

SCIENCE, 2008, 321 (5889) :702-705

[2]

Discovery of a novel series of nonacidic benzofuran EP1 receptor antagonists [J].

Allan, Amanda C. ;

Billinton, Andy ;

Brown, Susan H. ;

Chowdhury, Anita ;

Eatherton, Andrew J. ;

Fieldhouse, Charlotte ;

Giblin, Gerard M. P. ;

Goldsmith, Paul ;

Hall, Adrian ;

Hurst, David N. ;

Naylor, Alan ;

Rawlings, D. Anthony ;

Sime, Mairi ;

Scoccitti, Tiziana ;

Theobald, Pamela J. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (14) :4343-4348

[3]

Periganglionic inflammation elicits a distally radiating pain hypersensitivity by promoting COX-2 induction in the dorsal root ganglion [J].

Amaya, Fumimasa ;

Samad, Tarek A. ;

Barrett, Lee ;

Broom, Daniel C. ;

Woolf, Clifford J. .

PAIN, 2009, 142 (1-2) :59-67

[4]

The voltage-gated sodium channel Nav1.9 is an effector of peripheral inflammatory pain hypersensitivity [J].

Amaya, Fumimasa ;

Wang, Haibin ;

Costigan, Michael ;

Allchorne, Andrew J. ;

Hatcher, Jon P. ;

Egerton, Julie ;

Stean, Tania ;

Morisset, Valerie ;

Grose, David ;

Gunthorpe, Martin J. ;

Chessell, Iain P. ;

Tate, Simon ;

Green, Paula J. ;

Woolf, Clifford J. .

JOURNAL OF NEUROSCIENCE, 2006, 26 (50) :12852-12860

[5]

EFFECT OF BRADYKININ AND PROSTAGLANDINS ON THE RELEASE OF CALCITONIN GENE-RELATED PEPTIDE-LIKE IMMUNOREACTIVITY FROM THE RAT SPINAL-CORD INVITRO [J].

ANDREEVA, L ;

RANG, HP .

BRITISH JOURNAL OF PHARMACOLOGY, 1993, 108 (01) :185-190

[6]

DISTRIBUTION OF CYCLOOXYGENASE ISOFORMS IN MURINE CHRONIC GRANULOMATOUS INFLAMMATION - IMPLICATIONS FOR FUTURE ANTIINFLAMMATORY THERAPY [J].

APPLETON, I ;

TOMLINSON, A ;

MITCHELL, JA ;

WILLOUGHBY, DA .

JOURNAL OF PATHOLOGY, 1995, 176 (04) :413-420

[7]

Direct activation of rat spinal dorsal horn neurons by prostaglandin E2 [J].

Baba, H ;

Kohno, T ;

Moore, KA ;

Woolf, CJ .

JOURNAL OF NEUROSCIENCE, 2001, 21 (05) :1750-1756

[8]

Nociception in cyclooxygenase isozyme-deficient mice [J].

Ballou, LR ;

Botting, RM ;

Goorha, S ;

Zhang, JY ;

Vane, JR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (18) :10272-10276

[9]

Changes in the effect of spinal prostaglandin E2 during inflammation:: Prostaglandin E (EP1-EP4) receptors in spinal nociceptive processing of input from the normal or inflamed knee joint [J].

Bär, KJ ;

Natura, G ;

Telleria-Diaz, A ;

Teschner, P ;

Vogel, R ;

Vasquez, E ;

Schaible, HG ;

Ebersberger, A .

JOURNAL OF NEUROSCIENCE, 2004, 24 (03) :642-651

[10]

Cellular and Molecular Mechanisms of Pain [J].

Basbaum, Allan I. ;

Bautista, Diana M. ;

Scherrer, Gregory ;

Julius, David .

CELL, 2009, 139 (02) :267-284

← 1 2 3 4 5 6 7 8 9 10 →