Enhanced absorption of pour-on ivermectin formulation in rats by co-administration of the multidrug-resistant-reversing agent verapamil

被引：36

作者：

Alvinerie, M ^{[1
]}

Dupuy, J ^{[1
]}

Eeckhoutte, C ^{[1
]}

Sutra, JF ^{[1
]}

机构：

[1] INRA, Lab Pharmacol Toxicol, F-31931 Toulouse, France

来源：

PARASITOLOGY RESEARCH | 1999年 / 85卷 / 11期

关键词：

D O I：

10.1007/s004360050658

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The effect of verapamil, a multidrug-resistance (Mdr)-reversing agent on the absorption of a pour-on formulation of ivermectin was evaluated in rats. Absorption of ivermectin was effectively enhanced (40%) by the presence of verapamil, suggesting that absorption of ivermectin involves Mdr-P-glycoprotein and that verapamil should act as a competitive inhibitor for the transport and extrusion of ivermectin by P-glycoprotein. This hypothesis is consistent with other studies describing verapamil as a blocking agent of P-glycoprotein involved in the efflux of ivermectin in a resistant strain of Haemonchus contortus.

引用

页码：920 / 922

页数：3

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