Hypothesis: butyrate is not an HDAC inhibitor, but a product inhibitor of deacetylation

被引：18

作者：

Corfe, Bernard M. ^{[1
]}

机构：

[1] Univ Sheffield, Dept Oncol, Acad Unit Surg Oncol, Mol Gastroenterol Res Grp, Sheffield S10 2JF, S Yorkshire, England

来源：

MOLECULAR BIOSYSTEMS | 2012年 / 8卷 / 06期

关键词：

CHAIN FATTY-ACIDS; EPITHELIAL-CELLS; POSTTRANSLATIONAL MODIFICATIONS; LYSINE PROPIONYLATION; HISTONE DEACETYLATION; SODIUM-BUTYRATE; TRICHOSTATIN; BUTYRYLATION; ACTIVATION;

D O I：

10.1039/c2mb25028d

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The short-chain fatty acid butyrate is classically referred to as an inhibitor of histone deacetylases (HDACi), however evidence from direct assays is both sparse and contradictory. This paper assesses the strength of the historical evidence, potential gaps, inadequacies and simplifications in the butyrate-as-HDACi hypothesis. An alternate model to explain the action of butyrate is proposed wherein butyrate acts as a product inhibitor of deacetylation. The model makes testable predictions which may enable future determination of the mode of action of this and other SCFAs.

引用

页码：1609 / 1612

页数：4

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