Identification of CD137 as a potent monocyte survival factor

被引：68

作者：

Langstein, J ^{[1
]}

Schwarz, H ^{[1
]}

机构：

[1] Univ Regensburg, Dept Pathol, D-93042 Regensburg, Germany

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 1999年 / 65卷 / 06期

关键词：

macrophage colony-stimulating factor; cytokine receptor; human;

D O I：

10.1002/jlb.65.6.829

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

CD137 (ILA/4-1BB), a member of the tumor necrosis factor (TNF) receptor family, promotes adherence and prolongs survival of human peripheral monocytes, It induces a strong expression of macrophage colony-stimulating factor (M-CSF), an essential monocyte survival factor. Monocyte survival induced by CD137 is primarily mediated by M-CSF and to a lesser extent by granulocyte-macrophage colony-stimulating factor and IL-3. Survival and induction of M-CSF are mediated via reverse signaling through a CD137 ligand expressed constitutively by peripheral monocytes.

引用

页码：829 / 833

页数：5

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