The connection between transcription and genomic instability

被引：273

作者：

Aguilera, A ^{[1
]}

机构：

[1] Univ Sevilla, Fac Biol, Dept Genet, E-41012 Seville, Spain

来源：

EMBO JOURNAL | 2002年 / 21卷 / 03期

关键词：

class switching; somatic hypermutation; THO complex; transcription-associated mutation; transcription-associated recombination;

D O I：

10.1093/emboj/21.3.195

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Transcription is a central aspect of DNA metabolism that takes place on the same substrate as replication, repair and recombination. Not surprisingly, therefore, there is a physical and functional connection between these processes. In recent years, transcription has proven to be a relevant player in the maintenance of genome integrity and in the induction of genetic instability and diversity. The aim of this review is to provide an integrative view on how transcription can control different aspects of genomic integrity, by exploring different mechanisms that might be responsible for transcription-associated mutation (TAM) and transcription-associated recombination (TAR).

引用

页码：195 / 201

页数：7

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