IL4 and IL13 receptors share the gamma c chain and activate STAT6, STAT3 and STAT5 proteins in normal human B cells

被引：88

作者：

Rolling, C

Treton, D

Pellegrini, S

Galanaud, P

Richard, Y

机构：

[1] INST PARIS SUD CYTOKINES,INSERM U131,F-92140 CLAMART,FRANCE

[2] INST PASTEUR,INSERM U276,PARIS,FRANCE

来源：

FEBS LETTERS | 1996年 / 393卷 / 01期

关键词：

human B cell; IL13; signalling; IL4R alpha; IL2R gamma c; STAT protein;

D O I：

10.1016/0014-5793(96)00835-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

IL13 induces the same biological effects as IL4 in normal human B cells. We show that as in the IL4R complex, both IL4R alpha and IL2R gamma c are components of the IL13R and that both cytokines induced STAT6, STAT3 and STAT5 activation in B cells. In spite of this similar downstream signalling, IL4 and IL13 used a different set of Janus kinases: IL13 is unable to activate JAK1 and JAK3.

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页码：53 / 56

页数：4

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