The functional role of the novel biomarker karyopherin α 2 (KPNA2) in cancer

被引：125

作者：

Christiansen, Anders ^{[1
]}

Dyrskjot, Lars ^{[1
]}

机构：

[1] Aarhus Univ Hosp, Dept Mol Med, DK-8000 Aarhus, Denmark

来源：

CANCER LETTERS | 2013年 / 331卷 / 01期

关键词：

Karyopherin alpha 2 (KPNA2); Importin; Biomarker; Carcinogenesis; Nuclear transport; NUCLEAR-PROTEIN IMPORT; LOCALIZATION SIGNAL; SUBUNIT ALPHA-2; GENE-EXPRESSION; TERMINAL DOMAIN; BINDING; IDENTIFICATION; BRCA1; TRANSPORT; INHIBITION;

D O I：

10.1016/j.canlet.2012.12.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

In recent years, Karyopherin alpha 2 (KPNA2) has emerged as a potential biomarker in multiple cancer forms. The aberrant high levels observed in cancer tissue have been associated with adverse patient characteristics, prompting the idea that KPNA2 plays a role in carcinogenesis. This notion is supported by studies in cancer cells, where KPNA2 deregulation has been demonstrated to affect malignant transformation. By virtue of its role in nucleocytoplasmic transport, KPNA2 is implicated in the translocation of several cancer-associated proteins. We provide an overview of the clinical studies that have established the biomarker potential of KPNA2 and describe its functional role with an emphasis on established associations with cancer. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：18 / 23

页数：6

共 107 条

[1]

LOT1 (ZAC1/PLAGL1) and its family members: Mechanisms and functions [J].

Abdollahi, Abbas .

JOURNAL OF CELLULAR PHYSIOLOGY, 2007, 210 (01) :16-25

[2]

Localization of importin α (Rch1) at the plasma membrane and subcellular redistribution during lymphocyte activation [J].

Andrade, R ;

Alonso, R ;

Peña, R ;

Arlucea, J ;

Aréchaga, J .

CHROMOSOMA, 2003, 112 (02) :87-95

[3]

Acetylation of importin-α nuclear import factors by CBP/p300 [J].

Bannister, AJ ;

Miska, EA ;

Görlich, D ;

Kouzarides, T .

CURRENT BIOLOGY, 2000, 10 (08) :467-470

[4]

The Importin-Alpha/Nucleophosmin Switch Controls Taspase1 Protease Function [J].

Bier, Carolin ;

Knauer, Shirley K. ;

Docter, Dominic ;

Schneider, Guenter ;

Kraemer, Oliver H. ;

Stauber, Roland H. .

TRAFFIC, 2011, 12 (06) :703-714

[5]

Possible Role for Cellular Karyopherins in Regulating Polyomavirus and Papillomavirus Capsid Assembly [J].

Bird, Gregory ;

O'Donnell, Malinda ;

Moroianu, Junona ;

Garcea, Robert L. .

JOURNAL OF VIROLOGY, 2008, 82 (20) :9848-9857

[6]

Interferon regulatory factor-1 (IRF-1) exhibits tumor suppressor activities in breast cancer associated with caspase activation and induction of apoptosis [J].

Bouker, KB ;

Skaar, TC ;

Riggins, RB ;

Harburger, DS ;

Fernandez, DR ;

Zwart, A ;

Wang, A ;

Clarke, R .

CARCINOGENESIS, 2005, 26 (09) :1527-1535

[7]

Identification of a karyopherin α2 recognition site in PLAG1, which functions as a nuclear localization signal [J].

Braem, CV ;

Kas, K ;

Meyen, E ;

Debiec-Rychter, M ;

Van de Ven, WJM ;

Voz, ML .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (22) :19673-19678

[8]

Cleavage stage porcine embryos may have differing developmental requirements for Karyopherins α2 and α3 [J].

Cabot, RA ;

Prather, RS .

MOLECULAR REPRODUCTION AND DEVELOPMENT, 2003, 64 (03) :292-301

[9]

A karyopherin α2 nuclear transport pathway is regulated by glucose in hepatic and pancreatic cells [J].

Cassany, A ;

Guillemain, G ;

Klein, C ;

Dalet, V ;

Brot-Laroche, E ;

Leturque, A .

TRAFFIC, 2004, 5 (01) :10-19

[10]

The nuclear localization sequences of the BRCA1 protein interact with the importin-alpha subunit of the nuclear transport signal receptor [J].

Chen, CF ;

Li, S ;

Chen, YM ;

Chen, PL ;

Sharp, ZD ;

Lee, WH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (51) :32863-32868

← 1 2 3 4 5 6 7 8 9 10 →