Therapeutics for neonatal brain injury

被引：79

作者：

Gonzalez, Fernando F.

Ferriero, Donna M. ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Neonatal Brain Disorders Lab, Dept Pediat, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA

来源：

PHARMACOLOGY & THERAPEUTICS | 2008年 / 120卷 / 01期

关键词：

Neonatal stroke; Hypoxia; Ischemia; Neuroprotection; Neurogenesis;

D O I：

10.1016/j.pharmthera.2008.07.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Neonatal brain injury is an important cause of death and neurodevelopmental delay. Multiple pathways of oxidant stress, inflammation, and excitotoxicity lead to both early and late phases of cell damage and death. Therapies targeting these different pathways have shown potential in protecting the brain from ongoing injury. More recent therapies, such as growth factors, have demonstrated an ability to increase cell proliferation and repair over longer periods of time. Even though hypothermia, which decreases cerebral metabolism and possibly affects other mechanisms, may show some benefit in particular cases, no widely effective therapeutic interventions for human neonates exist. In this review, we summarize recent findings in neuroprotection and neurogenesis for the immature brain, including combination therapy to optimize repair. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：43 / 53

页数：11

共 231 条

[1]

Aher S., 2006, COCHRANE DB SYST REV, V3

[2]

Alkan T., 2001, Archives of Physiology and Biochemistry, V109, P135, DOI 10.1076/apab.109.2.135.4271

[3] Multiple pathways of neuroprotection against oxidative stress and excitotoxic injury in immature primary hippocampal neurons [J].