Malaria DNA vaccines in Aotus monkeys

被引:40
作者
Gramzinski, RA
Maris, DC
Doolan, D
Charoenvit, Y
Obaldia, N
Rossan, R
Sedegah, M
Wang, RB
Hobart, P
Margalith, M
Hoffman, S
机构
[1] USN,MED RES INST,MALARIA PROGRAM,BETHESDA,MD 20814
[2] GORGAS MEM LAB,PANAMA CITY,PANAMA
[3] PROMED INC,PANAMA CITY,PANAMA
[4] VIRAL INC,SAN DIEGO,CA
关键词
DNA vaccine; malaria; monkeys; Aotus; antibody;
D O I
10.1016/S0264-410X(96)00270-8
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In preparation for the development of DNA vaccines designed to produce protective antibodies against Plasmodium falciparum antigens (Ag), we conducted studies to optimize antibody responses in Aotus monkeys after immunization with the P. yoelli circumsporozoite (CSP) DNA vaccine. We demonstrate in Aotus monkeys that an intradermal route of immunization with a PyCSP plasmid DNA vaccine generates antibody responses equivalent to a multiple antigen peptide/adjuvant-based vaccine, and that these data support the use of the intradermal route for initial studies of the efficacy of DNA vaccines in inducing protective antibodies against P. falciparum antigens in Aotus monkeys. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码:913 / 915
页数:3
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