MicroRNA biomarkers in glioblastoma

被引：51

作者：

Hermansen, Simon Kjaer ^{[1
,2
]}

Kristensen, Bjarne Winther ^{[1
,2
]}

机构：

[1] Odense Univ Hosp, Dept Pathol, DK-5000 Odense C, Denmark

[2] Univ Southern Denmark, Inst Clin Res, Odense, Denmark

来源：

JOURNAL OF NEURO-ONCOLOGY | 2013年 / 114卷 / 01期

关键词：

MicroRNA; Glioblastoma; Biomarker; Review; MGMT PROMOTER METHYLATION; ADJUVANT TEMOZOLOMIDE; EXPRESSION PROFILE; RNA-INTERFERENCE; DOWN-REGULATION; PROLIFERATION; MICROARRAY; SURVIVAL; REVEALS; CANCERS;

D O I：

10.1007/s11060-013-1155-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent research suggests that deregulation of microRNAs (miRNAs) is involved in initiation and progression of many cancers, including gliomas and that miRNAs hold great potential as future diagnostic and therapeutic tools in cancer. MiRNAs are a class of short non-coding RNA sequences (18-24 nucleotides), which base-pair to target messenger RNA (mRNA) and thereby cause translational repression or mRNA degradation based on the level of complementarity between strands. Profiling miRNAs in clinical glioblastoma samples has shown aberrant expression of numerous miRNAs when compared to normal brain tissues. Understanding these alterations is key to developing new biomarkers and intelligent treatment strategies. This review presents an overview of current knowledge about miRNA alterations in glioblastoma while focusing on the clinical future of miRNAs as biomarkers and discussing the strengths and weaknesses of various methods used in evaluating their expression.

引用

页码：13 / 23

页数：11

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