Structure-activity relationship in two series of aminoalkyl substituted coumarin inhibitors of gyrase B

被引：51

作者：

Laurin, P

Ferroud, D

Schio, L

Klich, M

Dupuis-Hamelin, C

Mauvais, P

Lassaigne, P

Bonnefoy, A

Musicki, B

机构：

[1] Hoechst Marion Roussel, Med Chem, F-93235 Romainville, France

[2] Hoechst Marion Roussel, Infect Dis, F-93235 Romainville, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 19期

关键词：

D O I：

10.1016/S0960-894X(99)00492-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two series of aminosubstituted coumarins were synthesised and evaluated in vitro as inhibitors of DNA gyrase and as potential antibacterials. Novel novobiocin-like coumarins, 4-(dialkylamino)-methylcoumarins and 4-((2-alkylamino)ethoxy)coumarins, were discovered as gyrase B inhibitors with promising antibacterial activity in vitro. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：2875 / 2880

页数：6

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