Increased interleukin-18 content and angiogenic activity of sera from diabetic (Type 2) patients with background retinopathy

被引：61

作者：

Skopinski, P ^{[1
]}

Rogala, E

Duda-Król, B

Lipinska, A

Sommer, E

Chorotowska-Wynimko, J

Szaflik, J

Partyka, I

Skopinska-Rózewska, E

机构：

[1] Warsaw Med Univ, Fac Med 2, Dept Ophthalmol, Warsaw, Poland

[2] Warsaw Med Univ, Ctr Biostruct Res, Dept Histol & Embryol, Warsaw, Poland

[3] Natl Inst TB & Lung Dis, Dept Lung Dis 3, Warsaw, Poland

[4] Warsaw Med Univ, Fac Med 2, Dept Internal Med 3, Warsaw, Poland

[5] Warsaw Med Univ, Fac Dent, Dept Internal Med, Warsaw, Poland

[6] Natl Inst TB & Lung Dis, Dept Lab Diagnost & Immunol, Warsaw, Poland

[7] Warsaw Med Univ, Dept Pathol, Warsaw, Poland

来源：

JOURNAL OF DIABETES AND ITS COMPLICATIONS | 2005年 / 19卷 / 06期

关键词：

diabetes type 2; background retinopathy; angiogenesis; interleukin-18;

D O I：

10.1016/j.jdiacomp.2005.02.008

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Hyperglycaemia increases inflammatory cytokine concentration in the blood. Elevated levels of interleukin-18 (IL-18), a cytokine belonging to the interleukin-1 (IL-1) family, were recently reported in patients with Type 2 diabetes mellitus (DM2) and nephropathy. The aim of the present work was an examination of IL-18 concentration in the sera of elderly DM2 patients with nonproliferative retinopathy and age-matched control people and an estimation whether this cytokine plays pro- or anti-angiogenic role in in vivo angiogenic activity of their sera in mice cutaneous angiogenesis test. Recombinant human IL-18 injected intradermally to murine skin induced significant neovascular reaction. DM2 patients sera contained higher concentration of IL-1 8 and induced stronger neovascular reaction in mice skin than did the sera of corresponding control people. Sera from both groups of people after neutralization with antihuman IL-18 antibodies lost substantial part of their angiogenic activity. (C) 2005 Elsevier Inc. All rights reserved.

引用

页码：335 / 338

页数：4

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