MEG/EEG Source Reconstruction, Statistical Evaluation, and Visualization with NUTMEG

被引:91
作者
Dalal, Sarang S. [1 ,2 ,3 ]
Zumer, Johanna M. [4 ,5 ]
Guggisberg, Adrian G. [6 ]
Trumpis, Michael [7 ]
Wong, Daniel D. E. [8 ]
Sekihara, Kensuke
Nagarajan, Srikantan S.
机构
[1] Univ Konstanz, Dept Psychol, D-78457 Constance, Germany
[2] CERMEP, MEG Dept, F-69500 Lyon, France
[3] CNRS, INSERM U1028, UMR5292, Lyon Neurosci Res Ctr,Brain Dynam & Cognition Tea, F-69500 Lyon, France
[4] Univ Nottingham, Sir Peter Mansfield Magnet Resonance Ctr, Nottingham NG7 2RD, England
[5] Univ Hosp Geneva, Dept Clin Neurosci, Div Neurorehabil, CH-1211 Geneva, Switzerland
[6] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, Biomagnet Imaging Lab, San Francisco, CA 94143 USA
[7] Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5S 3G9, Canada
[8] Tokyo Metropolitan Univ, Dept Syst Design & Engn, Tokyo 1910065, Japan
基金
瑞士国家科学基金会;
关键词
PROBABILISTIC ALGORITHM; TEMPORAL DYNAMICS; BRAIN; MEG; EEG; LOCALIZATION; SCHIZOPHRENIA; SUPPRESSION; MODELS; ATLAS;
D O I
10.1155/2011/758973
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
NUTMEG is a source analysis toolbox geared towards cognitive neuroscience researchers using MEG and EEG, including intracranial recordings. Evoked and unaveraged data can be imported to the toolbox for source analysis in either the time or time-frequency domains. NUTMEG offers several variants of adaptive beamformers, probabilistic reconstruction algorithms, as well as minimum-norm techniques to generate functional maps of spatiotemporal neural source activity. Lead fields can be calculated from single and overlapping sphere head models or imported from other software. Group averages and statistics can be calculated as well. In addition to data analysis tools, NUTMEG provides a unique and intuitive graphical interface for visualization of results. Source analyses can be superimposed onto a structural MRI or headshape to provide a convenient visual correspondence to anatomy. These results can also be navigated interactively, with the spatial maps and source time series or spectrogram linked accordingly. Animations can be generated to view the evolution of neural activity over time. NUTMEG can also display brain renderings and perform spatial normalization of functional maps using SPM's engine. As a MATLAB package, the end user may easily link with other toolboxes or add customized functions.
引用
收藏
页数:17
相关论文
共 58 条
[1]  
Aguera P.-E., COMPUTATION IN PRESS
[2]   Signal quality of simultaneously recorded invasive and non-invasive EEG [J].
Ball, Tonio ;
Kern, Markus ;
Mutschler, Isabella ;
Aertsen, Ad ;
Schulze-Bonhage, Andreas .
NEUROIMAGE, 2009, 46 (03) :708-716
[3]  
Brookes M. J., 2010, BIOM P DUBR CROAT
[4]   Investigating spatial specificity and data averaging in MEG [J].
Brookes, Matthew J. ;
Zumer, Johanna M. ;
Stevenson, Claire M. ;
Hale, Joanne R. ;
Barnes, Gareth R. ;
Vrba, Jiri ;
Morris, Peter G. .
NEUROIMAGE, 2010, 49 (01) :525-538
[5]   Dipole localization using simulated intracerebral EEG [J].
Chang, N ;
Gulrajani, R ;
Gotman, J .
CLINICAL NEUROPHYSIOLOGY, 2005, 116 (11) :2707-2716
[6]   Spatiotemporal mapping of cortical activity accompanying voluntary movements using an event-related beamforming approach [J].
Cheyne, D ;
Bakhtazad, L ;
Gaetz, W .
HUMAN BRAIN MAPPING, 2006, 27 (03) :213-229
[7]  
Dalal S S, 2004, Neurol Clin Neurophysiol, V2004, P52
[8]   Five-dimensional neuroimaging: Localization of the time-frequency dynamics of cortical activity [J].
Dalal, Sarang S. ;
Guggisberg, Adrian G. ;
Edwards, Erik ;
Sekihara, Kensuke ;
Findlay, Anne M. ;
Canolty, Ryan T. ;
Berger, Mitchel S. ;
Knight, Robert T. ;
Barbaro, Nicholas M. ;
Kirsch, Heidi E. ;
Nagarajana, Srikantan S. .
NEUROIMAGE, 2008, 40 (04) :1686-1700
[9]   Modified beamformers for coherent source region suppression [J].
Dalal, Sarang S. ;
Sekihara, Kensuke ;
Nagarajan, Srikantan S. .
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 2006, 53 (07) :1357-1363
[10]   Simultaneous MEG and intracranial EEG recordings during attentive reading [J].
Dalal, Sarang S. ;
Baillet, Sylvain ;
Adam, Claude ;
Ducorps, Antoine ;
Schwartz, Denis ;
Jerbi, Karim ;
Bertrand, Olivier ;
Garnero, Line ;
Martinerie, Jacques ;
Lachaux, Jean-Philippe .
NEUROIMAGE, 2009, 45 (04) :1289-1304