Mitochondria as a Source of Reactive Oxygen and Nitrogen Species: From Molecular Mechanisms to Human Health

被引：368

作者：

Figueira, Tiago R. ^{[1
]}

Barros, Mario H. ^{[2
]}

Camargo, Anamaria A. ^{[3
,4
]}

Castilho, Roger F. ^{[1
]}

Ferreira, Julio C. B. ^{[5
]}

Kowaltowski, Alicia J. ^{[6
]}

Sluse, Francis E. ^{[7
]}

Souza-Pinto, Nadja C. ^{[6
]}

Vercesi, Anibal E. ^{[1
]}

机构：

[1] Univ Estadual Campinas, Dept Patol Clin, Fac Ciencias Med, BR-13083877 Campinas, SP, Brazil

[2] Univ Sao Paulo, Dept Microbiol, Inst Biomed Sci, Sao Paulo, Brazil

[3] Ludwig Inst Canc Res, Sao Paulo, Brazil

[4] Siriolibanese Hosp, Ctr Mol Oncol, Sao Paulo, Brazil

[5] Univ Sao Paulo, Dept Anat, Inst Biomed Sci, Sao Paulo, Brazil

[6] Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-01498 Sao Paulo, Brazil

[7] Univ Liege, Dept Life Sci, Fac Sci, Lab Bioenerget, Liege, Belgium

来源：

ANTIOXIDANTS & REDOX SIGNALING | 2013年 / 18卷 / 16期

基金：

巴西圣保罗研究基金会;

关键词：

NITRIC-OXIDE SYNTHASE; PROTEIN-KINASE-C; PERMEABILITY TRANSITION PORE; MANGANESE-SUPEROXIDE-DISMUTASE; DIETARY NITRATE SUPPLEMENTATION; COMPLEX-I DEFICIENCY; PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA; TRANSIENT FOREBRAIN ISCHEMIA; HYDROGEN-PEROXIDE PRODUCTION; MODERATE-INTENSITY EXERCISE;

D O I：

10.1089/ars.2012.4729

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Mitochondrially generated reactive oxygen species are involved in a myriad of signaling and damaging pathways in different tissues. In addition, mitochondria are an important target of reactive oxygen and nitrogen species. Here, we discuss basic mechanisms of mitochondrial oxidant generation and removal and the main factors affecting mitochondrial redox balance. We also discuss the interaction between mitochondrial reactive oxygen and nitrogen species, and the involvement of these oxidants in mitochondrial diseases, cancer, neurological, and cardiovascular disorders. Antioxid. Redox Signal. 18, 2029-2074.

引用

页码：2029 / 2074

页数：46

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