Interferon-α therapy associated with the development of sarcoidosis

被引：61

作者：

Pietropaoli, A ^{[1
]}

Modrak, J ^{[1
]}

Utell, M ^{[1
]}

机构：

[1] Univ Rochester, Med Ctr, Dept Med, Pulm & Crit Care Unit, Rochester, NY 14642 USA

来源：

CHEST | 1999年 / 116卷 / 02期

关键词：

autoimmune disease; interferon-alpha; sarcoidosis;

D O I：

10.1378/chest.116.2.569

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Interferons (IFNs) have been implicated in the pathogenesis of sarcoidosis. In particular, IFN-gamma has been linked to pulmonary macrophage activation, a characteristic feature of sarcoidosis. IFN-alpha is now being administered therapeutically in a variety of conditions. To date, IFN-alpha has not been implicated in the pathogenesis of sarcoidosis. We report the case of a 50-year-old woman who developed sarcoidosis while being treated with IFN-alpha for chronic myelogenous leukemia. Her disease activity correlated with the dosage of IFN-alpha. We speculate that the immunomodulatory effects of IFN-alpha triggered clinical manifestations of sarcoidosis in this patient.

引用

页码：569 / 572

页数：4

共 17 条

[1]

ABDI EA, 1987, CANCER, V59, P896, DOI 10.1002/1097-0142(19870301)59:5<896::AID-CNCR2820590507>3.0.CO

[2]

2-4

[3]

CONLON KC, 1990, CANCER, V65, P2237, DOI 10.1002/1097-0142(19900515)65:10<2237::AID-CNCR2820651013>3.0.CO

[4]

2-5

[5] INTERFERON-ALPHA IN MALIGNANT AND VIRAL DISEASES - A REVIEW [J].

DORR, RT .

DRUGS, 1993, 45 (02) :177-211

[6] HYDROGEN-PEROXIDE RELEASE BY ALVEOLAR MACROPHAGES FROM SARCOID PATIENTS AND BY ALVEOLAR MACROPHAGES FROM NORMALS AFTER EXPOSURE TO RECOMBINANT INTERFERONS ALPHA-A, BETA, AND GAMMA AND 1,25-DIHYDROXYVITAMIN-D3 [J].

FELS, AOS ;

NATHAN, CF ;

COHN, ZA .

JOURNAL OF CLINICAL INVESTIGATION, 1987, 80 (02) :381-386

[7] LYMPHOCYTE-T SUBSETS IN PERIPHERAL-BLOOD AND LUNG LAVAGE IN IDIOPATHIC PULMONARY FIBROSIS AND SARCOIDOSIS - ANALYSIS BY MONOCLONAL-ANTIBODIES AND FLOW-CYTOMETRY [J].

GINNS, LC ;

GOLDENHEIM, PD ;

BURTON, RC ;

COLVIN, RB ;

MILLER, LG ;

GOLDSTEIN, G ;

HURWITZ, C ;

KAZEMI, H .

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1982, 25 (01) :11-20

[8]

HUNNINGHAKE GW, 1984, AM REV RESPIR DIS, V130, P476

[9]

HUNNINGHAKE GW, 1986, ANN NY ACAD SCI, V456, P82

[10] Etiology of sarcoidosis [J].

Moller, DR .

CLINICS IN CHEST MEDICINE, 1997, 18 (04) :695-+

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