DETERMINATION OF METHYL ETHYL KETONE IN URINE SAMPLES BY HEADSPACE SOLID PHASE MICRO EXTRACTION (SPME) SAMPLING ASSOCIATED TO GAS CHROMATOGRAPHY WITH FLAME-IONIZATION DETECTOR (GC-FID)

被引：4

作者：

Antunes, Marina Venzon ^{[1
]}

Linden, Rafael ^{[1
]}

机构：

[1] Ctr Univ Feevale, Inst Ciencias Saude, BR-93352000 Novo Hamburgo, RS, Brazil

来源：

QUIMICA NOVA | 2008年 / 31卷 / 08期

关键词：

methyl ethyl ketone; SPME-GC-FID; biological monitoring;

D O I：

10.1590/S0100-40422008000800043

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Methyl ethyl ketone (MEK) is a solvent commonly used in chemical, paint and shoe industry. The aim of this study was to develop and validate a method for urinary quantification of MEK, employing headspace solid phase micro extraction sampling (SPME) coupled to gas chromatography with flame ionization detection (GC-FID). The calibration curve (y=4.6851x-0.0011) presented good linearity with r(2)=0.9993. Accuracy (94-109%), intra-assay precision (4.07-5.91%) and inter-assay precision (3.03-5.62%) were acceptable. The quantification limit was 0.19 mg/L. This low cost method can be used routinely in the biological monitoring of occupational exposure to MEK, according to the requirements of the Brazilian legislation.

引用

页码：2165 / 2168

页数：4

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