Naive to memory T-cell differentiation during homeostasis-driven proliferation

被引：22

作者：

Ge, Q

Hu, H

Eisen, HN

Chen, JZ

机构：

[1] MIT, Ctr Canc Res, Cambridge, MA 02139 USA

[2] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

MICROBES AND INFECTION | 2002年 / 4卷 / 05期

关键词：

naive T cells; memory T cells; homeostasis-driven proliferation; differentiation;

D O I：

10.1016/S1286-4579(02)01572-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During a homeostasis-driven T-cell proliferation, naive T cells stably acquire the cell surface markers and functional properties of antigen-induced memory T cells. Thus, in T-cell-deficient individuals, homeostasis-driven T-cell proliferation appears to restore only the memory T-cell compartment, whereas the reconstitution of the naive T-cell compartment depends on de novo T-cell development in the thymus. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

引用

收藏

页码：555 / 558

页数：4

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