Rapid, General Access to Chiral β-Fluoroamines and β,β-Difluoroamines via Organocatalysis

被引：75

作者：

Fadeyi, Olugbeminiyi O.

Lindsley, Craig W. ^{[1
]}

机构：

[1] Vanderbilt Univ, Dept Chem, Nashville, TN 37232 USA

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 04期

关键词：

FLUORINATION; DESIGN;

D O I：

10.1021/ol802930q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A rapid, general route to enantiopure beta-fluoroamines and beta,beta-difluoroamines has been developed employing organocatalysis in both a two-pot and a one-pot procedure. Both chemical yields (64-82%) and enantioselectivity (94-98% ee) were excellent and represent a significant improvement in the art of preparing chemically diverse beta-fluoroamines from readily available precursors.

引用

页码：943 / 946

页数：4

共 12 条

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