Identification of the target self-antigens in reperfusion injury

被引：176

作者：

Zhang, M

Alicot, EM

Chiu, I

Li, JN

Verna, N

Vorup-Jensen, T

Kessler, B

Shimaoka, M

Chan, R

Friend, D

Mahmood, U

Weissleder, R

Moore, FD

Carroll, MC ^{[1
]}

机构：

[1] CBR Inst Biomed Res Inc, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA

[5] Harvard Univ, Sch Med, Brigham & Womens Hosp, Boston, MA 02115 USA

[6] Massachusetts Gen Hosp, Ctr Mol Imaging Res, Boston, MA 02129 USA

[7] Harvard Univ, Sch Med, Boston, MA 02129 USA

[8] Declmmune Therapeut, Boston, MA 02115 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2006年 / 203卷 / 01期

关键词：

D O I：

10.1084/jem.20050390

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Reperfusion injury ( RI), a potential life-threatening disorder, represents an acute inflammatory response after periods of ischemia resulting from myocardial infarction, stroke, surgery, or trauma. The recent identification of a monoclonal natural IgM that initiates RI led to the identification of nonmuscle myosin heavy chain type II A and C as the self-targets in two different tissues. These results identify a novel pathway in which the innate response to a highly conserved self-antigen expressed as a result of hypoxic stress results in tissue destruction.

引用

收藏

页码：141 / 152

页数：12

相关论文

共 59 条

[1] Mast cell protease 5 mediates ischemia-reperfusion injury of mouse skeletal muscle [J].

Abonia, JP ;

Friend, DS ;

Austen, WG ;

Moore, FD ;

Carroll, MC ;

Chan, R ;

Afnan, J ;

Humbles, A ;

Gerard, C ;

Knight, P ;

Kanaoka, Y ;

Yasuda, S ;

Morokawa, N ;

Austen, KF ;

Stevens, RL ;

Gurish, MF .

JOURNAL OF IMMUNOLOGY, 2005, 174 (11) :7285-7291

[2] Novel multiwavelength microscopic scanner for mouse imaging [J].

Alencar, H ;

Mahmood, U ;

Kawano, Y ;

Hirata, T ;

Weissleder, R .

NEOPLASIA, 2005, 7 (11) :977-983

[3] DEVELOPMENT OF B-1 CELLS - SEGREGATION OF PHOSPHATIDYL CHOLINE-SPECIFIC B-CELLS TO THE B-1 POPULATION OCCURS AFTER IMMUNOGLOBULIN GENE-EXPRESSION [J].

ARNOLD, LW ;

PENNELL, CA ;

MCCRAY, SK ;

CLARKE, SH .

JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 179 (05) :1585-1595

[4] Murine hindlimb reperfusion injury can be initiated by a self-reactive monoclonal IgM [J].

Austen, WG ;

Zhang, M ;

Chan, R ;

Friend, D ;

Hechtman, HB ;

Carroll, MC ;

Moore, FD .

SURGERY, 2004, 136 (02) :401-406

[5] Intestinal ischemia-reperfusion injury is mediated by the membrane attack complex [J].

Austen, WG ;

Kyriakides, C ;

Favuzza, J ;

Wang, Y ;

Kohzik, L ;

Moore, FD ;

Hechtman, HB .

SURGERY, 1999, 126 (02) :343-348

[6] New concepts in reactive oxygen species and cardiovascular reperfusion physiology [J].

Becker, LB .

CARDIOVASCULAR RESEARCH, 2004, 61 (03) :461-470

[7] Generation of superoxide in cardiomyocytes during ischemia before reperfusion [J].

Becker, LB ;

Vanden Hoek, TL ;

Shao, ZH ;

Li, CQ ;

Schumacker, PT .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1999, 277 (06) :H2240-H2246

[8] Autoreactivity by design: Innate B and T lymphocytes [J].

Bendelac, A ;

Bonneville, M ;

Kearney, JF .

NATURE REVIEWS IMMUNOLOGY, 2001, 1 (03) :177-186

[9] Inferences, questions and possibilities in toll-like receptor signalling [J].

Beutler, B .

NATURE, 2004, 430 (6996) :257-263

[10] Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme [J].

Borodovsky, A ;

Ovaa, H ;

Kolli, N ;

Gan-Erdene, T ;

Wilkinson, KD ;

Ploegh, HL ;

Kessler, BM .

CHEMISTRY & BIOLOGY, 2002, 9 (10) :1149-1159

← 1 2 3 4 5 6 →