Nb3Sn superconductors show a dependence of the critical current and temperature on the strain state of the superconducting material. The basic causes of Nb3Sn strain effects, primarily differential thermal contraction between elements of the strand, have been known for 30 years, but have received more attention lately as part of a drive to achieve much higher operating current densities and make use of them in practical multistrand cables. The use of the cable-in-conduit (CICC) type of conductors to achieve high current capacity has proved popular, as the conductors offer good local cooling of the strands and distributed electrical contact between strands that is essential to provide stability against the inevitable current non-uniformity that arises with parallel connection of the strands. However, the essential openness of the cable means that the strands have to support local magnetic loads as well as being exposed to the overall magnet strain displacements. Simple structural models are developed based on mechanical measurements on cable-in-conduit conductors which are able to successfully simulate the measured superconducting performance. These suggest that degradation observed in large cables is due to a combination of the repeated bending strain experienced by the strands and filament fracture, which is starting to occur to a significant extent in some large cables. Superconducting performance improvements in strands can only be properly utilized with improved support of the strands in the cable, implying a more ordered structure than in a multistage.