Photo-induced cytotoxicity of water-soluble fullerene

被引：60

作者：

Nakajima, N ^{[1
]}

Nishi, C ^{[1
]}

Li, FM ^{[1
]}

Ikada, Y ^{[1
]}

机构：

[1] KYOTO UNIV,BIOMED ENGN RES CTR,SAKYO KU,KYOTO 606,JAPAN

来源：

FULLERENE SCIENCE AND TECHNOLOGY | 1996年 / 4卷 / 01期

关键词：

fullerene; cytotoxicity; superoxide; superoxide dismutase;

D O I：

10.1080/10641229608001533

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The reaction of C-60 with poly(ethylene glycol) having a terminal primary amino group or a mixture of ethylene diamine and poly(ethylene glycol) having terminal carboxyl groups resulted in formation of water-soluble C-60 conjugates. These conjugates showed strong cytotoxicity to L929 cells upon visible light irradiation as a result of superoxide production.

引用

页码：1 / 19

页数：19

共 24 条

[1] FORMATION OF SULFINYL OXIDE AND SINGLET OXYGEN IN THE REACTION OF THIANTHRENE CATION RADICAL AND SUPEROXIDE ION [J].

ANDO, W ;

KABE, Y ;

KOBAYASHI, S ;

TAKYU, C ;

YAMAGISHI, A ;

INABA, H .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1980, 102 (13) :4526-4528

[2] PHOTOPHYSICAL PROPERTIES OF C60 [J].

ARBOGAST, JW ;

DARMANYAN, AP ;

FOOTE, CS ;

RUBIN, Y ;

DIEDERICH, FN ;

ALVAREZ, MM ;

ANZ, SJ ;

WHETTEN, RL .

JOURNAL OF PHYSICAL CHEMISTRY, 1991, 95 (01) :11-12

[3] PHOTOPHYSICAL PROPERTIES OF C-70 [J].

ARBOGAST, JW ;

FOOTE, CS .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (23) :8886-8889

[4] BIOLOGICAL DEFENSE MECHANISMS - PRODUCTION BY LEUKOCYTES OF SUPEROXIDE A POTENTIAL BACTERICIDAL AGENT [J].

BABIOR, BM ;

KIPNES, RS ;

CURNUTTE, JT .

JOURNAL OF CLINICAL INVESTIGATION, 1973, 52 (03) :741-744

[5] TOXICITY DETERMINED INVITRO BY MORPHOLOGICAL ALTERATIONS AND NEUTRAL RED ABSORPTION [J].

BORENFREUND, E ;

PUERNER, JA .

TOXICOLOGY LETTERS, 1985, 24 (2-3) :119-124

[6]

DOUGHERTY TJ, 1976, CANCER RES, V36, P2330

[7] INHIBITION OF THE HIV-1 PROTEASE BY FULLERENE DERIVATIVES - MODEL-BUILDING STUDIES AND EXPERIMENTAL-VERIFICATION [J].

FRIEDMAN, SH ;

DECAMP, DL ;

SIJBESMA, RP ;

SRDANOV, G ;

WUDL, F ;

KENYON, GL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (15) :6506-6509

[8]

HOCHLEY K, 1986, FOOD CHEM TOXICOL, V24, P473

[9]

JOHNSTON RB, 1978, J EXP MED, V148, P115

[10]

KAMPE KD, 1995, LIEBIGS ANN, P115

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