t(7;11)(p15;p15) chronic myeloid leukaemia developed into blastic transformation showing a novel NUP98/HOXA11 fusion

被引：24

作者：

Suzuki, A

Ito, Y

Sashida, G

Honda, S

Katagiri, T

Fujino, T

Nakamura, T

Ohyashiki, K

机构：

[1] Tokyo Med Univ, Dept Internal Med 1, Shinjuku Ku, Tokyo 1600023, Japan

[2] Japanese Fdn Canc Res, Inst Canc, Dept Carcinogenesis, Tokyo 170, Japan

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2002年 / 116卷 / 01期

关键词：

CML; AML; NUP98; HOXA11; t(7; 11);

D O I：

10.1046/j.1365-2141.2002.03246.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We encountered a patient with Philadelphia-negative chronic myeloid leukaemia, with t(7;11)(p15:p15), in whom acute leukaemia phase (acute myeloid leukaemia-M2 morphology) developed within a short period. We detected a novel gene fusion between NUP98 and HOXA11 both in the chronic phase and in the acute leukaemia phase in this case. Although it is well known that a fusion of NUP98-HOXA9 in myeloid malignancies Is created by the t(7:11)(p15;p15), this case suggests the possibility that HOXA11 might be another partner gene for NUP98 in t(7;11)(p15:p15) leukaemia.

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页码：170 / 172

页数：3

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