Differentiation and function of Foxp3+ effector regulatory T cells

被引：202

作者：

Cretney, Erika ^{[1
,2
]}

Kallies, Axel ^{[1
,2
]}

Nutt, Stephen L. ^{[1
,2
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, Parkville, Vic, Australia

[2] Univ Melbourne, Dept Med Biol, Parkville, Vic 3052, Australia

来源：

TRENDS IN IMMUNOLOGY | 2013年 / 34卷 / 02期

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

regulatory T cell; transcription; B lymphocyte-induced maturation protein-1; interleukin-10; differentiation; autoimmune disease; TRANSCRIPTIONAL REPRESSOR BLIMP-1; TRANSPLANTATION TOLERANCE; RHEUMATOID-ARTHRITIS; PERIPHERAL-BLOOD; HOST-DEFENSE; NAIVE-LIKE; INTERLEUKIN-10; EXPRESSION; TUMOR; INFLAMMATION;

D O I：

10.1016/j.it.2012.11.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Regulatory T (Treg) cells are essential for immunological tolerance and homeostasis. Although forkhead box (Fox)p3 is continually required to reinforce the Treg cell program, Treg cells can also undergo stimulus-specific differentiation that is regulated by transcription factors typically associated with the differentiation of conventional CD4(+) T cells. This results in effector Treg (eTreg) cells with unique migratory and functional properties matched to the stimulus that elicited the initial response. Despite this functional and transcriptional heterogeneity, expression of the transcription factor B lymphocyte-induced maturation protein (Blimp)-1, a key player in late B cell and conventional T cell differentiation, is common to all eTreg cells. Here, we discuss the factors that control the differentiation of eTreg cells and their importance in disease settings.

引用

页码：74 / 80

页数：7

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