QSAR of cytochrome P450

被引：49

作者：

Hansch, C ^{[1
]}

Mekapati, SB ^{[1
]}

Kurup, A ^{[1
]}

Verma, RP ^{[1
]}

机构：

[1] Pomona Coll, Dept Chem, Claremont, CA 91711 USA

来源：

DRUG METABOLISM REVIEWS | 2004年 / 36卷 / 01期

关键词：

QSAR; cytochrome P450; ADME;

D O I：

10.1081/DMR-120028428

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The cytochrome P450 class of enzymes is an extremely important and complex group. It has a significant place in ADME (adsorption, distribution, metabolism, elimination) that those developing new drugs must be concerned with. While there are various ways in which organic compounds can undergo metabolic attack, P450 is probably the most important. Recently, Lewis (2000) reviewed his extensive studies on P450 and efforts to use QSAR to gain a deeper understanding on this important class of enzymes. We have also been interested in the QSAR of P450 enzymes, but much has appeared since our last review (Hansch and Zhang, 1993).

引用

页码：105 / 156

页数：52

共 54 条

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