The leptin receptor mediates apparent autocrine regulation of leptin gene expression

被引：71

作者：

Zhang, YY

Olbort, M

Schwarzer, K

NuessleinHildesheim, B

Nicolson, M

Murphy, E

Kowalski, TJ

Schmidt, I

Leibel, RL

机构：

[1] MAX PLANCK INST PHYSIOL & CLIN RES,WG KERCKHOFF INST,D-61231 BAD NAUHEIM,GERMANY

[2] AMGEN INC,THOUSAND OAKS,CA 91320

[3] NEW YORK HOSP,CORNELL MED CTR,EW BOURNE RES LAB,WHITE PLAINS,NY 10605

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 240卷 / 02期

关键词：

D O I：

10.1006/bbrc.1997.7622

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The possibility that the leptin receptor (LEPR) mediates autocrine regulation of leptin expression in adipose tissue was examined in 10-day-old Zucker rat pups with different copy numbers of the leptin receptor mutation (Lepr(fa)). Plasma leptin concentrations and adipose tissue mRNA levels for leptin were related to copy number of the mutation (fa/fa > fa/+ > +/+). These relationships were independent of plasma insulin concentration. Reduced copy number for the functional leptin receptor apparently results in a diminished negative feedback signal to the leptin gene in adipose tissue. Thus, leptin appears to close a short regulatory loop controlling its own synthesis in adipose tissue. (C) 1997 Academic Press.

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收藏

页码：492 / 495

页数：4

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