Diabetic Cardiomyopathy What Is It and Can It Be Fixed?

被引：521

作者：

Dillmann, Wolfgang H. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Med, Div Endocrinol Metab, 9500 Gilman Dr MC0618, La Jolla, CA 92093 USA

来源：

CIRCULATION RESEARCH | 2019年 / 124卷 / 08期

基金：

美国国家卫生研究院;

关键词：

calcium; coronary artery disease; diabetes mellitus; diabetic cardiomyopathy; heart failure; mitochondria; GENE-THERAPY; HEART; MECHANISMS;

D O I：

10.1161/CIRCRESAHA.118.314665

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Diabetic cardiomyopathy was initially described as a human pathophysiological condition in which heart failure occurred in the absence of coronary artery disease, hypertension, and valvular heart disease. Recent studies in diabetic animal models identify decreased cardiomyocyte function as an important mediating mechanism for heart failure. Decreased cardiomyocyte function is in part mediated by abnormal mitochondrial calcium handling and a decreased free matrix calcium level which could be a good target for new therapeutic interventions.

引用

页码：1160 / 1162

页数：3

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