Improved outcome of allogeneic bone marrow transplantation due to breastfeeding-induced tolerance to maternal antigens

被引：31

作者：

Aoyama, Kazutoshi ^{[1
]}

Koyama, Motoko

Matsuoka, Ken-ichi ^{[1
]}

Hashimoto, Daigo ^{[2
]}

Ichinohe, Tatsuo ^{[3
]}

Harada, Mine

Akashi, Koichi

Tanimoto, Mitsune ^{[1
]}

Teshima, Takanori ^{[2
]}

机构：

[1] Okayama Univ, Grad Sch Med & Dent, Okayama, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Ctr Cellular & Mol Med, Fukuoka 812, Japan

[3] Kyoto Univ, Grad Sch Med, Dept Hematol Oncol, Kyoto, Japan

来源：

BLOOD | 2009年 / 113卷 / 08期

关键词：

VERSUS-HOST-DISEASE; REGULATORY T-CELLS; ORAL TOLERANCE; CORD BLOOD; MECHANISM; MILK; MICROCHIMERISM; EXPRESSION; INDUCTION; ALLOGRAFT;

D O I：

10.1182/blood-2008-05-155283

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Exposure of offspring to noninherited maternal antigens (NIMAs) during pregnancy may have an impact on transplantations performed later in life. Using a mouse model, we recently showed that bone marrow transplantation (BMT) from NIMA-exposed offspring to the mother led to a reduction of graft-versus-host disease (GVHD). Since offspring can also be exposed to NIMAs by breastfeeding after birth, we tested whether breast milk could mediate the tolerogenic NIMA effect. We found that oral exposure to NIMAs by breastfeeding alone was sufficient to reduce GVHD, and that in utero exposure to NIMAs is required for maximum reduction of GVHD. The tolerogenic milk effects disappeared when donor mice were injected with CD25 monoclonal antibodies during the lactation period, suggesting a CD4(+)CD25(+) regulatory T cell dependent mechanism. Our results suggest a previously unknown impact of breastfeeding on the outcome of transplantation. (Blood. 2009;113:1829-1833)

引用

页码：1829 / 1833

页数：5

共 36 条

[1]

Exosomes with immune modulatory features are present in human breast milk [J].