C8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties

被引：51

作者：

Banwell, MG

Bezos, A

Burns, C

Kruszelnicki, I

Parish, CR

Su, S

Sydnes, MO

机构：

[1] Australian Natl Univ, Res Sch Chem, Canberra, ACT 0200, Australia

[2] Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 0200, Australia

[3] Cytopia Pty Ltd, Baker Heart Res Inst, Melbourne, Vic 3004, Australia

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 01期

关键词：

anti-angiogenic; cis-stilbene; combretastatin A4; phenanthroquinolizidine;

D O I：

10.1016/j.bmcl.2005.09.032

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four enantiomerically pure monoseco-analogues, 5, 7, 9, and 11, of the phenanthroquinolizidine alkaloid julandine (1) and four of congener cryptopleurine (2), viz. compounds 6, 8, 10, and 12, have been prepared and subjected to preliminary biological evaluation. These analogues show dramatically reduced cytotoxicity compared with the parent system 2 but they are, nevertheless, potent anti-angiogenic agents. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：181 / 185

页数：5

共 32 条

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