Blood serum miRNA: Non-invasive biomarkers for Alzheimer's disease

被引：261

作者：

Geekiyanage, Hirosha ^{[5
]}

Jicha, Gregory A. ^{[4
]}

Nelson, Peter T. ^{[3
]}

Chan, Christina ^{[1
,2
,5
]}

机构：

[1] Michigan State Univ, Dept Chem Engn & Mat Sci, E Lansing, MI 48824 USA

[2] Michigan State Univ, Dept Biochem & Mol Biol, E Lansing, MI 48824 USA

[3] Univ Kentucky, Div Neuropathol, Dept Pathol, Lexington, KY 40536 USA

[4] Univ Kentucky, Dept Neurol, Lexington, KY 40536 USA

[5] Michigan State Univ, Genet Program, E Lansing, MI 48824 USA

来源：

EXPERIMENTAL NEUROLOGY | 2012年 / 235卷 / 02期

基金：

美国国家科学基金会;

关键词：

Alzheimer's disease; microRNA; Blood serum; CIRCULATING MICRORNA; CEREBROSPINAL-FLUID; DIABETES-MELLITUS; EXPRESSION; DEMENTIA; PROTEIN; BETA; GENDER; PLASMA; IDENTIFICATION;

D O I：

10.1016/j.expneurol.2011.11.026

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

There is an urgent need to identify non-invasive biomarkers for the detection of sporadic Alzheimer's disease (AD). We previously studied microRNAs (miRNAs) in AD autopsy brain samples and reported a connection between miR-137, -181c, -9, -29a/b and AD, through the regulation of ceramides. In this study, the potential role of these miRNAs as diagnostic markers for AD was investigated. We identified that these miRNAs were down-regulated in the blood serum of probable AD patients. The levels of these miRNAs were also reduced in the serum of AD risk factor models. Although the ability of these miRNAs to conclusively diagnose for AD is currently unknown, our findings suggest a potential use for circulating miRNAs, along with other markers, as non-invasive and relatively inexpensive biomarkers for the early diagnosis of AD, however, with further research and validation. (c) 2011 Published by Elsevier Inc.

引用

页码：491 / 496

页数：6

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