Executive cognitive functioning and risk for substance abuse

Individuals with a substance use disorder (SUD) exhibit deficits in executive cognitive functioning (ECF). ECF is involved in the regulation of goal-directed behavior and includes abilities such as attentional control, strategic goal planning, organization, and cognitive flexibility. The prefrontal cortex is believed to be the primary cortical substrate that subserves ECE Children deemed at high risk for drug abuse because they have parents with SUD similarly demonstrate cognitive limitations suggesting an ECF deficit. High-risk children, as a group, also exhibit deviations in temperament, an attenuated amplitude of the P300 event-related potential, and heightened aggressivity compared with control groups. These latter characteristics are associated with low ECF capacity and are believed to reflect dysfunction within the prefrontal cortex. It is hypothesized that deviations on these traits form a core disorder of affective, cognitive, and behavioral dysregulation that serves as a general vulnerability factor for SUD.