Exercise accelerates wound healing among healthy older adults: A preliminary investigation

被引:86
作者
Emery, CF
Kiecolt-Glaser, JK
Glaser, R
Malarkey, WB
Frid, DJ
机构
[1] Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA
[2] Ohio State Univ, Dept Internal Med, Columbus, OH 43210 USA
[3] Ohio State Univ, Dept Psychiat, Columbus, OH 43210 USA
[4] Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA
[5] Ohio State Univ, Inst Behav Med Res, Columbus, OH 43210 USA
[6] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA
来源
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2005年 / 60卷 / 11期
关键词
D O I
10.1093/gerona/60.11.1432
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background. Older adults are likely to experience delayed rates of wound healing, impaired neuroendocrine responsiveness, and increased daily stress. Exercise activity has been shown to have a positive effect on physiological functioning and psychological functioning among older adults. This study evaluated the effect of a 3-month exercise program on wound healing, neuroendocrine function, and perceived stress among healthy older adults. Methods. Twenty-eight healthy older adults (mean age 61.0 +/- 5.5 years) were assigned randomly to an exercise activity group (n = 13) or to a nonexercise control group (n = 15). One month following baseline randomization, after exercise participants had acclimated to the exercise routine, all participants underwent an experimental wound procedure. Wounds were measured 3 times per week until healed to calculate rate of wound healing. All participants completed assessments of exercise endurance, salivary cortisol, and self-reported stress prior to randomization and at the conclusion of the intervention. Results. Exercise participants achieved significant improvements in cardiorespiratory fitness, as reflected by increased oxygen consumption (VO(2)max) and exercise duration. Wound healing occurred at a significantly faster rate in the exercise group [mean = 29.2 (9.0) days] than in the nonexercise group [38.9 (7.4) days; p = .012]. Exercise participants also experienced increased cortisol secretion during stress testing following the intervention. Group differences in wound healing and neurcendocrine responsiveness were found despite low levels of self-reported stress. Conclusions. A relatively short-term exercise intervention is associated with enhanced rates of wound healing among healthy older adults. Thus, exercise activity may be an important component of health care to promote wound healing.
引用
收藏
页码:1432 / 1436
页数:5
相关论文
共 24 条
[1]   Stress-induced changes in skin barrier function in healthy women [J].
Altemus, M ;
Rao, B ;
Dhabhar, FS ;
Ding, WH ;
Granstein, R .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2001, 117 (02) :309-317
[2]   EXERCISE TRAINING IN HEALTHY TYPE-A MIDDLE-AGED MEN - EFFECTS ON BEHAVIORAL AND CARDIOVASCULAR-RESPONSES [J].
BLUMENTHAL, JA ;
EMERY, CF ;
WALSH, MA ;
COX, DR ;
KUHN, CM ;
WILLIAMS, RB ;
WILLIAMS, RS .
PSYCHOSOMATIC MEDICINE, 1988, 50 (04) :418-433
[3]   GROWTH-HORMONE, EXERCISE, AND AGING - THE FUTURE OF THERAPY FOR THE FRAIL ELDERLY [J].
BORST, SE ;
MILLARD, WJ ;
LOWENTHAL, DT .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1994, 42 (05) :528-535
[4]  
CHVAPIL M, 1982, OTOLARYNG CLIN N AM, V15, P259
[5]   A GLOBAL MEASURE OF PERCEIVED STRESS [J].
COHEN, S ;
KAMARCK, T ;
MERMELSTEIN, R .
JOURNAL OF HEALTH AND SOCIAL BEHAVIOR, 1983, 24 (04) :385-396
[6]  
COHEN S, 1988, CLAR SYMP, P31
[7]  
Cohen S., 1995, MEASURING STRESS GUI
[8]   Enhancing versus suppressive effects of stress hormones on skin immune function [J].
Dhabhar, FS ;
McEwen, BS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (03) :1059-1064
[9]  
DiGiovanna A.G., 1994, HUMAN AGING BIOL PER
[10]   AEROBIC EXERCISE TRAINING AND IMPROVED NEUROPSYCHOLOGICAL FUNCTION OF OLDER INDIVIDUALS [J].
DUSTMAN, RE ;
RUHLING, RO ;
RUSSELL, EM ;
SHEARER, DE ;
BONEKAT, HW ;
SHIGEOKA, JW ;
WOOD, JS ;
BRADFORD, DC .
NEUROBIOLOGY OF AGING, 1984, 5 (01) :35-42