Rebuilding the road to cancer

被引：38

作者：

Weitzman, JB ^{[1
]}

Yaniv, M ^{[1
]}

机构：

[1] Inst Pasteur, Unite Virus Oncogenes, F-75724 Paris 15, France

来源：

NATURE | 1999年 / 400卷 / 6743期

关键词：

D O I：

10.1038/22637

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

After more than 15 years of trying, researchers have managed to convert normal human cells into tumour cells in a culture dish. This achievement should help identify new players in tumour formation, and develop treatments that target them.

引用

页码：401 / 402

页数：2

共 11 条

[1] Extension of life-span by introduction of telomerase into normal human cells [J].

Bodnar, AG ;

Ouellette, M ;

Frolkis, M ;

Holt, SE ;

Chiu, CP ;

Morin, GB ;

Harley, CB ;

Shay, JW ;

Lichtsteiner, S ;

Wright, WE .

SCIENCE, 1998, 279 (5349) :349-352

[2] Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization [J].

Counter, CM ;

Hahn, WC ;

Wei, WY ;

Caddle, SD ;

Beijersbergen, RL ;

Lansdorp, PM ;

Sedivy, JM ;

Weinberg, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (25) :14723-14728

[3] Creation of human tumour cells with defined genetic elements [J].

Hahn, WC ;

Counter, CM ;

Lundberg, AS ;

Beijersbergen, RL ;

Brooks, MW ;

Weinberg, RA .

NATURE, 1999, 400 (6743) :464-468

[4] LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS [J].

HAYFLICK, L .

EXPERIMENTAL CELL RESEARCH, 1965, 37 (03) :614-&

[5] Lessons from hereditary colorectal cancer [J].

Kinzler, KW ;

Vogelstein, B .

CELL, 1996, 87 (02) :159-170

[6] Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells [J].

Kiyono, T ;

Foster, SA ;

Koop, JI ;

McDougall, JK ;

Galloway, DA ;

Klingelhutz, AJ .

NATURE, 1998, 396 (6706) :84-88

[7] TUMORIGENIC CONVERSION OF PRIMARY EMBRYO FIBROBLASTS REQUIRES AT LEAST 2 COOPERATING ONCOGENES [J].

LAND, H ;

PARADA, LF ;

WEINBERG, RA .

NATURE, 1983, 304 (5927) :596-602

[8] hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization [J].

Meyerson, M ;

Counter, CM ;

Eaton, EN ;

Ellisen, LW ;

Steiner, P ;

Caddle, SD ;

Ziaugra, L ;

Beijersbergen, RL ;

Davidoff, MJ ;

Liu, QY ;

Bacchetti, S ;

Haber, DA ;

Weinberg, RA .

CELL, 1997, 90 (04) :785-795

[9] Absence of cancer-associated changes in human fibroblasts immortalized with telomerase [J].

Morales, CP ;

Holt, SE ;

Ouellette, M ;

Kaur, KJ ;

Yan, Y ;

Wilson, KS ;

White, MA ;

Wright, WE ;

Shay, JW .

NATURE GENETICS, 1999, 21 (01) :115-118

[10] THE ROLES OF INDIVIDUAL POLYOMA-VIRUS EARLY PROTEINS IN ONCOGENIC TRANSFORMATION [J].

RASSOULZADEGAN, M ;

COWIE, A ;

CARR, A ;

GLAICHENHAUS, N ;

KAMEN, R ;

CUZIN, F .

NATURE, 1982, 300 (5894) :713-718

← 1 2 →