Phomacins: Three novel antitumor cytochalasan constituents produced by a Phoma sp.

被引：31

作者：

Alvi, KA

Nair, B

Pu, H

Ursino, R

Gallo, C

Mocek, U

机构：

[1] Panlabs, Inc., Bothell, WA 98011-8805

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1997年 / 62卷 / 07期

关键词：

D O I：

10.1021/jo962321s

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three novel cytochalasans, phomacins A, B and C, were isolated from a fermentation broth of the fungus Phoma sp. and purified by HSCCC (high speed countercurrent chromatography) followed by HPLC. The structures were determined by 1D and 2D NMR techniques, All three compounds have shown potent inhibitory activity against the HT29 colonic adenocarcinoma cell line.

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页码：2148 / 2151

页数：4

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