Nuclear envelope:: Torn apart at mitosis

被引：10

作者：

Gönczy, P ^{[1
]}

机构：

[1] Swiss Inst Expt Canc Res, ISREC, CH-1066 Epalinges, Switzerland

来源：

CURRENT BIOLOGY | 2002年 / 12卷 / 07期

关键词：

D O I：

10.1016/S0960-9822(02)00781-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The findings of two recent studies suggest a novel mechanism for nuclear envelope breakdown in which cytoplasmic dynein anchored on the outside of the nucleus generates tension, thus triggering tearing of the nuclear envelope.

引用

页码：R242 / R244

页数：3

共 20 条

[1] FORMATION OF SPINDLE FIBERS, KINETOCHORE ORIENTATION, AND BEHAVIOR OF NUCLEAR ENVELOPE DURING MITOSIS IN ENDOSPERM - FINE STRUCTURAL AND IN VITRO STUDIES [J].

BAJER, A ;

MOLEBAJE.J .

CHROMOSOMA, 1969, 27 (04) :448-&

[2] Nuclear envelope breakdown proceeds by microtubule-induced tearing of the lamina [J].

Beaudouin, J ;

Gerlich, D ;

Daigle, N ;

Eils, R ;

Ellenberg, J .

CELL, 2002, 108 (01) :83-96

[3] Dynein and dynactin are localized to astral microtubules and at cortical sites in mitotic epithelial cells [J].

Busson, S ;

Dujardin, D ;

Moreau, A ;

Dompierre, J ;

De Mey, JR .

CURRENT BIOLOGY, 1998, 8 (09) :541-544

[4] Microtubules orient the mitotic spindle in yeast through dynein-dependent interactions with the cell cortex [J].

Carminati, JL ;

Stearns, T .

JOURNAL OF CELL BIOLOGY, 1997, 138 (03) :629-641

[5]

Georgatos SD, 1997, J CELL SCI, V110, P2129

[6] Cytoplasmic dynein is required for distinct aspects of MTOC positioning, including centrosome separation, in the one cell stage Caenorhabditis elegans embryo [J].

Gönczy, P ;

Pichler, S ;

Kirkham, M ;

Hyman, AA .

JOURNAL OF CELL BIOLOGY, 1999, 147 (01) :135-150

[7]

HAMAGUCHI Y, 1993, BIOIMAGES, V1, P129

[8] The Aspergillus cytoplasmic dynein heavy chain and NUDF localize to microtubule ends and affect microtubule dynamics [J].

Han, GS ;

Liu, B ;

Zhang, J ;

Zuo, WQ ;

Morris, NR ;

Xiang, X .

CURRENT BIOLOGY, 2001, 11 (09) :719-724

[9] MUTATIONS OF PHOSPHORYLATION SITES IN LAMIN-A THAT PREVENT NUCLEAR LAMINA DISASSEMBLY IN MITOSIS [J].

HEALD, R ;

MCKEON, F .

CELL, 1990, 61 (04) :579-589

[10] ULTRASTRUCTURAL ANALYSIS OF MITOSIS AND CYTOKINESIS IN ZYGOTE OF SEA-URCHIN, ARBACIA-PUNCTULATA [J].

LONGO, FJ .

JOURNAL OF MORPHOLOGY, 1972, 138 (02) :207-&

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