Examining the gateway to the limbic system with diffusion tensor imaging: The perforant pathway in dementia

被引:89
作者
Kalus, P
Slotboom, J
Gallinat, J
Mahlberg, R
Cattapan-Ludewig, K
Wiest, R
Nyffeler, T
Buri, C
Federspiel, A
Kunz, D
Schroth, G
Kiefer, C
机构
[1] Charite Univ Med, Dept Psychiat, Berlin, Germany
[2] Univ Bern, Inst Diagnost & Intervent Radiol, Bern, Switzerland
[3] Univ Hosp Bern, Psychiat Outpatient Dept, CH-3010 Bern, Switzerland
[4] Univ Hosp Bern, Div Neuropsychol Rehabil, CH-3010 Bern, Switzerland
[5] Univ Hosp Bern, Psychiat Clin, CH-3010 Bern, Switzerland
关键词
Alzheimer's disease; mild cognitive impairment; diffusion tensor imaging; perforant pathway; hippocampus; entorhinal cortex;
D O I
10.1016/j.neuroimage.2005.10.035
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Current treatments for Alzheimer's disease (AD) are only able to slow the progression of mental deterioration, making early and reliable diagnosis an essential part of an), promising therapeutic strategy. In the initial stages of AD, the first neuropathological alterations occur in the perforant pathway (PP), a large neuronal fiber tract located at the entrance to the limbic system. However, to date, there is no sensitive diagnostic tool for performing in vivo assessments of this structure. In the present bimodal magnetic resonance imaging (MRI) study, we examined 10 elderly controls, 10 subjects suffering from mild cognitive impairment (MCI), and 10 AD patients in order to evaluate the sensitivity of diffusion tensor imaging (DTI), a new MRI technique, for detecting changes in the PP. Furthermore, the diagnostic explanatory power of DTI data of the PP should be compared to high-resolution MRI volumetry and intervoxel coherences (COH) of the hippocampus and the entorhinal cortex, two limbic regions also involved in the pathophysiology of earl), AD. DTI revealed a marked decrease in COH values in the PP region of MCI (right side: 26%, left side: 29%, as compared to controls) and AD patients (right side: 37%, left side: 43%, as compared to controls). Reductions in COH values of the PP region were significantly correlated with cognitive impairment. DTI data of the PP zone were the only parameter differing significantly between control subjects and MCI patients, while the volumetric measures and the COH values of the hippocampus and the entorhinal cortex did not. DTI of medial temporal brain regions is a promising non-invasive tool for the in vivo diagnosis of the early,preclinical stages of AD. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:713 / 720
页数:8
相关论文
共 50 条
[1]   Spatial transformations of diffusion tensor magnetic resonance images [J].
Alexander, DC ;
Pierpaoli, C ;
Basser, PJ ;
Gee, JC .
IEEE TRANSACTIONS ON MEDICAL IMAGING, 2001, 20 (11) :1131-1139
[2]  
[Anonymous], 1998, J COMPUT ASSIST TOMO
[3]   Correlations between mental state and quantitative neuropathology in the Vienna longitudinal study on dementia [J].
Bancher, C ;
Jellinger, K ;
Lassmann, H ;
Fischer, P ;
Leblhuber, F .
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 1996, 246 (03) :137-146
[4]   ESTIMATION OF THE EFFECTIVE SELF-DIFFUSION TENSOR FROM THE NMR SPIN-ECHO [J].
BASSER, PJ ;
MATTIELLO, J ;
LEBIHAN, D .
JOURNAL OF MAGNETIC RESONANCE SERIES B, 1994, 103 (03) :247-254
[5]   White matter damage in Alzheimer's disease assessed in vivo using diffusion tensor magnetic resonance imaging [J].
Bozzali, M ;
Falini, A ;
Franceschi, M ;
Cercignani, M ;
Zuffi, M ;
Scotti, G ;
Comi, G ;
Filippi, M .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2002, 72 (06) :742-746
[7]   Frequency of stages of Alzheimer-related lesions in different age categories [J].
Braak, H ;
Braak, E .
NEUROBIOLOGY OF AGING, 1997, 18 (04) :351-357
[8]   NEUROPATHOLOGICAL STAGING OF ALZHEIMER-RELATED CHANGES [J].
BRAAK, H ;
BRAAK, E .
ACTA NEUROPATHOLOGICA, 1991, 82 (04) :239-259
[9]  
Buxbaum JD, 1998, J NEUROSCI, V18, P9629
[10]   Early diagnosis of Alzheimer's disease: contribution of structural neuroimaging [J].
Chetelat, G ;
Baron, JC .
NEUROIMAGE, 2003, 18 (02) :525-541