Dietary activators of Sirt1

被引：61

作者：

Allard, Joanne S. ^{[1
]}

Perez, Evelyn ^{[1
]}

Zou, Sige ^{[1
]}

de Cabo, Rafael ^{[1
]}

机构：

[1] NIA, Lab Expt Gerontol, NIH, Baltimore, MD 21224 USA

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2009年 / 299卷 / 01期

关键词：

Calorie restriction; Lifespan; Resveratrol; Sirtuins; LIFE-SPAN EXTENSION; SMALL-MOLECULE ACTIVATORS; GENE-EXPRESSION PROFILE; NF-KAPPA-B; CALORIE RESTRICTION; SACCHAROMYCES-CEREVISIAE; CAENORHABDITIS-ELEGANS; CELL-SURVIVAL; DROSOPHILA-MELANOGASTER; MITOCHONDRIAL-FUNCTION;

D O I：

10.1016/j.mce.2008.10.018

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Calorie restriction (CR) is a non-genetic manipulation that reliably results in extended lifespan of several species ranging from yeast to dogs. The lifespan extension effect of CR has been strongly associated with an increased level and activation of the silent information regulator 2 (Sir2) histone deacetylase and its mammalian ortholog Sirt1. This association led to the search for potential Sirt1-activating, life-extending molecules. This review briefly outlines the experimental findings on resveratrol and other dietary activators of Sirt1. (C) 2008 Published by Elsevier Ireland Ltd.

引用

页码：58 / 63

页数：6

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