The structural basis for deadenylation by the CCR4-NOT complex

被引：53

作者：

Bartlam, Mark ^{[1
]}

Yamamoto, Tadashi ^{[2
]}

机构：

[1] Nankai Univ, Coll Life Sci, Tianjin Key Lab Prot Sci, Tianjin 300071, Peoples R China

[2] Univ Tokyo, Inst Med Sci, Div Oncol, Minato Ku, Tokyo 1088639, Japan

来源：

PROTEIN & CELL | 2010年 / 1卷 / 05期

基金：

中国国家自然科学基金;

关键词：

MESSENGER-RNA DEADENYLASE; SACCHAROMYCES-CEREVISIAE; TRANSCRIPTIONAL COMPLEX; DIFFERENTIALLY AFFECTS; GENE-EXPRESSION; PROTEIN-KINASE; CAF1; PROTEINS; YEAST; COMPONENT; BTG2;

D O I：

10.1007/s13238-010-0060-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The CCR4-NOT complex is a highly conserved, multifunctional machinery controlling mRNA metabolism. Its components have been implicated in several aspects of mRNA and protein expression, including transcription initiation, elongation, mRNA degradation, ubiquitination, and protein modification. In this review, we will focus on the role of the CCR4-NOT complex in mRNA degradation. The complex contains two types of deadenylase enzymes, one belonging to the DEDD-type family and one belonging to the EEP-type family, which shorten the poly(A) tails of mRNA. We will review the present state of structure-function analyses into the CCR4-NOT deadenylases and summarize current understanding of their roles in mRNA degradation. We will also review structural and functional work on the Tob/BTG family of proteins, which are known to interact with the CCR4-NOT complex and which have been reported to suppress deadenylase activity in vitro.

引用

页码：443 / 452

页数：10

共 60 条

[1]

Identification of a ubiquitin-protein ligase subunit within the CCR4-NOT transcription repressor complex [J].