A dynamic view of mHLA-DR expression in management of severe septic patients

被引：26

作者：

Monneret, Guillaume ^{[1
,2
]}

Lepape, Alain ^{[2
,3
]}

Venet, Fabienne ^{[1
,2
]}

机构：

[1] Hop Edouard Herriot, Immunol Lab, Hosp Civils Lyon, F-69437 Lyon 03, France

[2] Univ Lyon 1, Hosp Civils Lyon, Fac Med Laennec, Equipe Accueil Mixte 4174, F-69372 Lyon 08, France

[3] Lyon Sud Univ Hosp, Hosp Civils Lyon, Intens Care Unit, F-69495 Pierre Benite, France

来源：

CRITICAL CARE | 2011年 / 15卷 / 05期

关键词：

INFECTION; SEPSIS;

D O I：

10.1186/cc10452

中图分类号：

R4 [临床医学];

学科分类号：

100218 [急诊医学];

摘要：

Increasing evidence suggests that the secondary phase of sepsis (that is, after the first proinflammatory hours) is characterized by the occurrence of a systemic failure of the immune system. In the most immunodepressed patients, therapies could be used to restore normal immune functions. However, biomarkers need to be developed to beforehand specifically identify these patients. Of these biomarkers, diminished monocyte HLA-DR expression has rapidly become the most popular. Herein, novel perspectives regarding monocyte HLA-DR assessed as a dynamic parameter in septic patients will be discussed in the context of a recently published study investigating daily evolution of monocyte HLA-DR with regard to 28 day-mortality after severe sepsis.

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