From expression to signaling: Roles of TREM-1 and TREM-2 in innate immunity and bacterial infection

被引：172

作者：

Sharif, Omar ^{[1
,2
]}

Knapp, Sylvia ^{[1
,2
]}

机构：

[1] Med Univ Vienna, Ctr Mol Med, Austrian Acad Sci, A-1090 Vienna, Austria

[2] Med Univ Vienna, Dept Med 1, Div Infect Dis & Trop Med, A-1090 Vienna, Austria

来源：

IMMUNOBIOLOGY | 2008年 / 213卷 / 9-10期

关键词：

Bacterial infection; Innate immunity; TREM-1; TREM-2;

D O I：

10.1016/j.imbio.2008.07.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Triggering receptor expressed on myeloid cells (TREM) proteins play important roles in innate and adaptive immunity. Since the discovery of TREM-1 and TREM-2 in 2000, the field has exploded over the past 8 years and currently TREM-1 is thought of as an amplifier of the immune response, while TREM-2 is believed to be a negative regulator. Here, we discuss the current state of the literature on TREMs, with a focus on TREM-1 and TREM-2 and their expression, signaling in mononuclear phagocytes and roles in innate immunity and bacterial infection. (C) 2008 Elsevier GmbH. All rights reserved.

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收藏

页码：701 / 713

页数：13

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