Human leukocyte antigen class I supertypes influence susceptibility and severity of tuberculosis

被引:32
作者
Balamurugan, A
Sharma, SK
Mehra, NK [1 ]
机构
[1] All India Inst Med Sci, Dept Tumor Immunol & Immunogenet, New Delhi 110029, India
[2] All India Inst Med Sci, Dept Med, New Delhi 110029, India
关键词
D O I
10.1086/381689
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Although both differential susceptibility to Mycobacterium tuberculosis infection and disease pathogenesis depend on a multitude of factors, elucidation of specific host genetic markers, particularly those in the human major histocompatibilty complex, is important. The present study is an attempt to delineate human leukocyte antigen (HLA) class I association in tuberculosis (TB) on the basis of a shared sequence motif in peptide-binding pockets of HLA molecules. In patients with pulmonary TB and miliary/ disseminated TB, we observed significantly increased frequencies of A3-like supertypes and decreased frequencies of A1-like supertypes. These 2 positively and negatively associated supertypes (allele groups) share a similar peptide-binding motif, except for residues in pocket F of the HLA class I molecules. In addition, the HLA-Cw specificities that are major ligands for killer cell immunoglobulin-like (inhibitory) receptors (KIRs), particularly KIR2DL1 (Cw2, Cw4, and CW5) and KIR2DL2 (Cw1, Cw3, and Cw7), were found more frequently among patients with TB, which suggests a possible inhibition of natural killer cell activity against the infected target cells. The results of the present study suggest that the frequent occurrence of HLA class I specificities comprising an A3-like peptide-binding motif and the increased occurrence of ligands for KIR2DL in TB together may influence the outcome of TB.
引用
收藏
页码:805 / 811
页数:7
相关论文
共 36 条
  • [1] Variations in the Nrampi gene and susceptibility to tuberculosis in West Africans
    Bellamy, R
    Ruwende, C
    Corrah, T
    McAdam, KPWJ
    Whittle, HC
    Hill, AVS
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (10) : 640 - 644
  • [2] Genetic susceptibility to tuberculosis in human populations
    Bellamy, R
    [J]. THORAX, 1998, 53 (07) : 588 - 593
  • [3] Natural killer cells in antiviral defense: Function and regulation by innate cytokines
    Biron, CA
    Nguyen, KB
    Pien, GC
    Cousens, LP
    Salazar-Mather, TP
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, 1999, 17 : 189 - 220
  • [4] Differences between HLA-B44 and HLA-B60 in patients with smear-positive pulmonary tuberculosis and exposed controls
    Bothamley, GH
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1999, 179 (04) : 1051 - 1052
  • [5] ASSOCIATION OF PULMONARY TUBERCULOSIS AND HLA IN SOUTH-INDIA
    BRAHMAJOTHI, V
    PITCHAPPAN, RM
    KAKKANAIAH, VN
    SASHIDHAR, M
    RAJARAM, K
    RAMU, S
    PALANIMURUGAN, K
    PARAMASIVAN, CN
    PRABHAKAR, R
    [J]. TUBERCLE, 1991, 72 (02): : 123 - 132
  • [6] ALLOANTIGEN RECOGNITION BY 2 HUMAN NATURAL-KILLER-CELL CLONES IS ASSOCIATED WITH HLA-C OR A CLOSELY LINKED GENE
    COLONNA, M
    SPIES, T
    STROMINGER, JL
    CICCONE, E
    MORETTA, A
    MORETTA, L
    PENDE, D
    VIALE, O
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (17) : 7983 - 7985
  • [7] THE PROTECTIVE IMMUNE-RESPONSE TO MYCOBACTERIUM-TUBERCULOSIS
    COOPER, AM
    FLYNN, JL
    [J]. CURRENT OPINION IN IMMUNOLOGY, 1995, 7 (04) : 512 - 516
  • [8] Global burden of tuberculosis - Estimated incidence, prevalence, and mortality by country
    Dye, C
    Scheele, S
    Dolin, P
    Pathania, V
    Raviglione, RC
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 282 (07): : 677 - 686
  • [9] MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I-RESTRICTED T-CELLS ARE REQUIRED FOR RESISTANCE TO MYCOBACTERIUM-TUBERCULOSIS INFECTION
    FLYNN, JL
    GOLDSTEIN, MM
    TRIEBOLD, KJ
    KOLLER, B
    BLOOM, BR
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (24) : 12013 - 12017
  • [10] García VE, 1999, J IMMUNOL, V162, P6114