Association between plasma free haem and incidence of vaso-occlusive episodes and acute chest syndrome in children with sickle cell disease

被引：65

作者：

Adisa, Olufolake A. ^{[1
,2
,3
]}

Hu, Yijuan ^{[4
]}

Ghosh, Samit ^{[1
]}

Aryee, Doreen ^{[1
]}

Osunkwo, Ifeyinwa ^{[1
,2
,3
]}

Ofori-Acquah, Solomon F. ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Pediat, Div Hematol Oncol & Bone Marrow Transplantat, Atlanta, GA 30322 USA

[2] Childrens Healthcare Atlanta, Aflac Canc Ctr, Atlanta, GA USA

[3] Childrens Healthcare Atlanta, Blood Disorders Serv, Atlanta, GA USA

[4] Emory Univ, Rollins Sch Publ Hlth, Dept Biostat & Bioinformat, Atlanta, GA 30322 USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2013年 / 162卷 / 05期

关键词：

extracellular haem; sickle cell disease; vaso-occlusive pain crisis; acute chest syndrome; PULMONARY-HYPERTENSION; RISK; OXYGENASE-1; HEMOGLOBIN; ANEMIA; DEATH;

D O I：

10.1111/bjh.12445

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

We tested the hypothesis that extracellular haem is linked to the incidence of acute complications of sickle cell disease (SCD). Using multivariable regression analysis, higher plasma free haem, but not total plasma haem, was associated with increased odds of vaso-occlusive crisis (VOC) [P=0.028, odds ratio (OR); 2.05, 95% Confidence Interval (CI)=1.08-3.89] and acute chest syndrome (ACS) [P=0.016, OR; 2.56, CI=1.19, 5.47], after adjusting for age and gender in children with SCD. These findings suggest that haem and factors that influence its concentration in plasma may be informative of the risk of VOC and ACS in SCD patients.

引用

页码：702 / 705

页数：4

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