Effect of zinc and vitamin A supplementation on antibody responses to a pneumococcal conjugate vaccine in HIV-positive injection drug users: A randomized trial

被引：19

作者：

Deloria-Knoll, M

Steinhoff, M

Semba, RD

Nelson, K

Vlahov, D

Meinert, CL

机构：

[1] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA

[2] NIAID, Bethesda, MD 20892 USA

来源：

VACCINE | 2006年 / 24卷 / 10期

关键词：

vitamin A; zinc; pneumococcal vaccine; HIV;

D O I：

10.1016/j.vaccine.2005.09.047

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

HIV-infected individuals have impaired immune responses to vaccines and high rates of pneumococcal disease. The effect of vitamin A and zinc supplementation on the immunogenicity of a 7-valent pneumococcal CRM-197 conjugate vaccine (PC-7) was evaluated in 118 HIV+ injection drug users. Subjects were randomized to oral 400,000 IU vitamin A, 300 mg zinc, vitamin A + zinc, or placebo, then immunized. Geometric mean titer increased 1.3-3.3-fold for all pneumococcal serotypes. PC-7 elicited an immune response in HIV-infected adults but neither vitamin A nor zinc altered the immunogenicity of the evaluated vaccines. (c) 2005 Elsevier Ltd. All rights reserved.

引用

收藏

页码：1670 / 1679

页数：10

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