Multiple effects of repetitive transcranial magnetic stimulation on neuropsychiatric disorders

被引：12

作者：

Ikeda, Tetsurou ^{[1
,3
]}

Kurosawa, Masaru ^{[1
]}

Morimoto, Chikao ^{[3
]}

Kitayama, Shigeo ^{[2
]}

Nukina, Nobuyuki ^{[1
]}

机构：

[1] RIKEN, Brain Sci Inst, Lab Struct Neuropathol, Wako, Saitama 3510198, Japan

[2] Okayama Univ, Grad Sch Med & Dent, Dept Dent Pharmacol, Okayama 7008525, Japan

[3] Univ Tokyo, Inst Med Sci, Minato Ku, Tokyo 1088639, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2013年 / 436卷 / 02期

基金：

日本学术振兴会;

关键词：

rTMS; Period; 2; HSP70; Dopamine receptor 2; EXPANDED POLYGLUTAMINE; DOPAMINE RELEASE; CORTEX; EXPRESSION; DISEASE; BRAIN; TOOL;

D O I：

10.1016/j.bbrc.2013.03.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Repetitive transcranial magnetic stimulation (rTMS) is a new tool that has been used for the treatment of patients with neuropsychiatric disorders. However, the mechanisms underlying the effects of rTMS are still unclear. We analyzed the changes in mRNA expression in mouse brain that occurred after rTMS with an Affymetrix GeneChip. Following 20 days of rTMS, many genes were differentially expressed in the mouse brain. Downregulation of Period 2 and 3 mRNA expression levels and a subsequent decrease in food and water intake were observed. HSP70 mRNA expression levels were upregulated after transient and chronic rTMS. In N2A 150Q cells, an upregulation of HSP70 mRNA and protein levels and subsequent cell-protective effects were observed after chronic rTMS. In addition, dopamine receptor 2 mRNA expression levels were downregulated, and a subsequent decrease in the binding of [H-3]raclopride was observed. These results indicated that the modulation of several genes may be involved in the therapeutic mechanisms of chronic rTMS for patients with neuropsychiatric disorders. (C) 2013 Published by Elsevier Inc.

引用

页码：121 / 127

页数：7

共 18 条

[1]

BARKER AT, 1987, NEUROSURGERY, V20, P100

[2]

CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2

[3]

Therapeutic efficacy of bilateral prefrontal slow repetitive transcranial magnetic stimulation in depressed patients with Parkinson's disease: An open study [J].

Dragasevic, N ;

Potrebic, A ;

Damjanovic, A ;

Stefanova, E ;

Kostic, VS .

MOVEMENT DISORDERS, 2002, 17 (03) :528-532

[4]

George MS, 1996, J NEUROPSYCH CLIN N, V8, P373

[5]

Transcranial magnetic stimulation -: Applications in neuropsychiatry [J].

George, MS ;

Lisanby, SH ;

Sackeim, HA .

ARCHIVES OF GENERAL PSYCHIATRY, 1999, 56 (04) :300-311

[6]

Transcranial magnetic stimulation and the human brain [J].

Hallett, M .

NATURE, 2000, 406 (6792) :147-150

[7]

Modulation of monoamine transporter expression and function by repetitive transcranial magnetic stimulation [J].

Ikeda, T ;

Kurosawa, M ;

Uchikawa, C ;

Kitayama, S ;

Nukina, N .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 327 (01) :218-224

[8]

Effects of acute repetitive transcranial magnetic stimulation on dopamine release in the rat dorsolateral striatum [J].

Kanno, M ;

Matsumoto, M ;

Togashi, H ;

Yoshioka, M ;

Mano, Y .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 2004, 217 (01) :73-81

[9]

Decreased expression of hypothalamic neuropeptides in Huntington disease transgenic mice with expanded polyglutamine-EGFP fluorescent aggregates [J].

Kotliarova, S ;

Jana, NR ;

Sakamoto, N ;

Kurosawa, M ;

Miyazaki, H ;

Nekooki, M ;

Doi, H ;

Machida, Y ;

Wong, HK ;

Suzuki, T ;

Uchikawa, C ;

Kotliarov, Y ;

Uchida, K ;

Nagao, Y ;

Nagaoka, U ;

Tamaoka, A ;

Oyanagi, K ;

Oyama, F ;

Nukina, N .

JOURNAL OF NEUROCHEMISTRY, 2005, 93 (03) :641-653

[10]

High density synthetic oligonucleotide arrays [J].

Lipshutz, RJ ;

Fodor, SPA ;

Gingeras, TR ;

Lockhart, DJ .

NATURE GENETICS, 1999, 21 (Suppl 1) :20-24

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