Accessories to addiction: G protein regulators play a key role in cocaine seeking and neuroplasticity

被引：11

作者：

Kelley, AE

Schiltz, CA

机构：

[1] Univ Wisconsin, Madison Med Sch, Dept Psychiat, Neurosci Training Program, Madison, WI 53705 USA

[2] Univ Wisconsin, Madison Med Sch, Med Scientist Training Program, Madison, WI 53705 USA

来源：

NEURON | 2004年 / 42卷 / 02期

关键词：

D O I：

10.1016/S0896-6273(04)00223-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The prefrontal cortex mediates many aspects of addiction. In this issue of Neuron, Bowers et al. demonstrate that an activator of G protein signaling (AGS3) is persistently upregulated in the prefrontal cortex after cessation of chronic cocaine treatment. Furthermore, they find that AGS3 is responsible for altered behavior, such as enhanced drug seeking, and altered neurotransmission in cocaine-treated rats, representing a novel therapeutic target.

引用

页码：181 / 183

页数：3

共 11 条

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