Angiogenesis: A Team Effort Coordinated by Notch

被引：631

作者：

Phng, L. -K. ^{[1
]}

Gerhardt, Holger ^{[1
]}

机构：

[1] Canc Res UK, Vasc Biol Lab, London Res Inst, London WC2A 3PX, England

来源：

DEVELOPMENTAL CELL | 2009年 / 16卷 / 02期

关键词：

ENDOTHELIAL-GROWTH-FACTOR; ARTERIAL-VENOUS DIFFERENTIATION; TRANSCRIPTION FACTOR HESR1; INHIBITS TUMOR-GROWTH; ARTERIOVENOUS-MALFORMATIONS; VASCULAR MORPHOGENESIS; SIGNALING PATHWAYS; IN-VITRO; CELL; VEGF;

D O I：

10.1016/j.devcel.2009.01.015

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The past two decades of angiogenesis research have identified a wealth of pro- and antiangiogenic signals originating from the tissue environment, which control blood vessel density and function. Understanding when and how blood vessels respond to the combination of signals they encounter to achieve a balanced cellular response is a major challenge for the field of developmental and tumor angiogenesis. This review focuses on how endothelial cell-cell communication via the Notch pathway contributes to this signal integration and is essential for functional vessel patterning.

引用

页码：196 / 208

页数：13

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