Metabolism and the Paradoxical Effects of Arsenic: Carcinogenesis and Anticancer

被引：50

作者：

Cui, Xing ^{[1
]}

Kobayashi, Yayoi ^{[2
]}

Akashi, Makoto ^{[3
]}

Okayasu, Ryuichi ^{[1
]}

机构：

[1] Natl Inst Radiol Sci, Res Ctr Charged Particle Therapy, Inage Ku, Chiba 2638555, Japan

[2] Natl Inst Environm Studies, Environm Hlth Sci Div, Tsukuba, Ibaraki 3058506, Japan

[3] Natl Inst Radiol Sci, Res Ctr Radiat Emergency Med, Dept Radiat Emergency Med, Inage Ku, Chiba 2638555, Japan

来源：

CURRENT MEDICINAL CHEMISTRY | 2008年 / 15卷 / 22期

关键词：

D O I：

10.2174/092986708785747526

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Arsenic, a known human carcinogen, can induce tumors of the skin, urinary bladder, liver and lung etc.. On the other hand, arsenic is also a novel promising anticancer agent, and can be used effectively to treat acute promyelocytic leukemia (APL) and some other tumors. These paradoxical effects of arsenic not only result from direct or indirect influences on the genetic and epigenetic levels, but are also closely correlated with unique arsenic metabolism. This article reviews our recent studies as well as other reports on arsenic metabolism and epigenetic changes of DNA methylation during its metabolism. We also summarize the clinical use of arsenic trioxide ( As2O3) to date and discuss new therapeutic strategies such as concurrent arsenic-radiation therapy to achieve local tumor control and enhance the radiosensitivity of solid tumors.

引用

页码：2293 / 2304

页数：12

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