Structure-activity relationships in 3-oxo-1,4-benzodiazepine-2-acetic acid GPIIb/IIIa antagonists. The 2-benzazepine series

被引：8

作者：

Miller, WH

Ali, FE

Bondinell, WE

Callahan, JF

Calvo, RR

Eggleston, DS

Haltiwanger, RC

Huffman, WF

Hwang, SM

Jakas, DR

Keenan, RM

Koster, PF

Ku, TW

Kwon, C

Newlander, KA

Nichols, AJ

Parker, MF

Samanen, JM

Southall, LS

Takata, DT

Uzinskas, IN

Valocik, RE

VaskoMoser, JA

Wong, AS

Yellin, TO

Yuan, CCK

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT PLC, DEPT PHYS & STRUCT CHEM, KING OF PRUSSIA, PA 19406 USA

[2] SMITHKLINE BEECHAM PHARMACEUT PLC, DEPT CELLULAR BIOCHEM, KING OF PRUSSIA, PA 19406 USA

[3] SMITHKLINE BEECHAM PHARMACEUT PLC, DEPT PHARMACOL, DIV RES & DEV, KING OF PRUSSIA, PA 19406 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 21期

关键词：

D O I：

10.1016/0960-894X(96)00432-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In an investigation of the contribution of N-1 to the binding, antiaggregatory, and oral activity in 3-oxo-1,4-benzodiazepine 2-acetic acid based GPIIb/IIIa antagonists, a series of 2-benzazepine analogs, wherein N-1 of the 1,4-benzodiazepine nucleus has been replaced by a methylene group, was examined. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2481 / 2486

页数：6

共 20 条

[1] CONFORMATIONALLY CONSTRAINED PEPTIDES AND SEMIPEPTIDES DERIVED FROM RGD AS POTENT INHIBITORS OF THE PLATELET FIBRINOGEN RECEPTOR AND PLATELET-AGGREGATION [J].

ALI, FE ;

BENNETT, DB ;

CALVO, RR ;

ELLIOTT, JD ;

HWANG, SM ;

KU, TW ;

LAGO, MA ;

NICHOLS, AJ ;

ROMOFF, TT ;

SHAH, DH ;

VASKO, JA ;

WONG, AS ;

YELLIN, TO ;

YUAN, CK ;

SAMANEN, JM .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (06) :769-780

[2]

ALI FE, 1992, PEPTIDES CHEM BIOL, P761

[3] A SHORT LARGE-SCALE SYNTHESIS OF (+/-)SARKOMYCIN ESTERS [J].

AMRI, H ;

RAMBAUD, M ;

VILLIERAS, J .

TETRAHEDRON LETTERS, 1989, 30 (52) :7381-7382

[4]

Bondinell W E, 1994, Bioorg Med Chem, V2, P897, DOI 10.1016/S0968-0896(00)82039-8

[5]

BONDINELL WE, UNPUB

[6]

CLAKRE CT, 1978, J CHEM SOC P1, P1088

[7]

Cook Nigel S., 1994, Drugs of the Future, V19, P135

[8]

Frantantoni J. C., 1990, AM J CLIN PHARM, V94, P613

[9]

GARTNER TK, 1985, J BIOL CHEM, V260, P1891

[10]

HECK RF, 1982, ORG REACTIONS, V27, P345

← 1 2 →